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      Apendicitis aguda, bacteriemia y artritis: manifestaciones de infección por Yersinia enterocolitica en un adolescente

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          Abstract

          Resumen La infección por Yersinia enterocolitica produce un amplio espectro de manifestaciones clínicas. En los lactantes y niños pequeños, la diarrea aguda es la forma de presentación más frecuente. En niños mayores y adolescentes el síndrome seudoapendicular debido a ileítis terminal y/o adenitis mesentérica constituye una manifestación típica. Se han descrito complicaciones postinfecciosas de mecanismo inmunoalérgico. Se presenta el caso de un adolescente de 15 años que es intervenido quirúrgicamente con diagnóstico de apendicitis aguda. En la evolución reinstala fiebre y artritis de codo derecho; en el hemocultivo se aísla Y. enterocolitica. Se revisa la patogenia y manifestaciones clínicas de la infección por este agente y se analiza el posible mecanismo de la complicación articular.

          Translated abstract

          Summary Yersinia enterocolitica produces a wide spectrum of clinical manifestations. In infants and young children, the most common presentation is acute diarrhea. In elder children and adolescents a typical manifestation is a seudoapendicular syndrome due to terminal ileitis and/or mesenteric adenitis. Postinfectious complications of immunoallergic mechanism were also described. We present a case of a 15 year old adolescent who underwent surgery with the diagnosis of acute appendicitis. In the evolution he reinstalls fever and right elbow arthritis. Y. Enterolocitica vas isolated in blood culture. We review the pathogenesis and clinical manifestations of the infection by this agent and discuss the possible mechanism of articular complication.

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          Most cited references23

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          Etiology of children's diarrhea in Montevideo, Uruguay: associated pathogens and unusual isolates.

          We studied microorganisms associated with infant diarrhea in a group of 256 children admitted to a public pediatric hospital in Montevideo, Uruguay. Diagnostic procedures were updated to optimize detection of potential pathogens, which were found in 63.8% of cases, and to be able to define their characteristics down to molecular or antigenic type. Coinfection with two or more agents was detected in more than one-third of positive studies. Escherichia coli enteric virotypes, especially enteropathogenic E. coli (EPEC), were shown to be prevalent. Rotavirus, Cryptosporidium, Campylobacter (mainly Campylobacter jejuni), and Shigella flexneri were also often identified. Enterotoxigenic E. coli, Salmonella, and Giardia lamblia were sporadically recognized. Unusual findings included two enteroinvasive E. coli strains, one Shigella dysenteriae 2 isolate, and a non-O:1 Vibrio cholerae culture. EPEC bacteria and S. flexneri (but not Salmonella) showed unusually frequent antimicrobial resistance, especially towards beta-lactam antibiotics, which is the subject of ongoing work.
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            Antibiotic treatment of Yersinia enterocolitica septicemia: a retrospective review of 43 cases.

            Of 53 documented cases of Yersinia enterocolitica septicemia reported to the French national registry between 1985 and 1991, 43 files contained sufficient information on antibiotic treatment to be analyzed retrospectively. All patients had at least two positive cultures of blood collected before the initiation of treatment. All strains were susceptible in vitro to the antibiotics that are usually active against gram-negative rods except for older beta-lactam agents (i.e., aminopenicillins and first-generation cephalosporins). No multiresistant strain was isolated. Only four (7.5%) of the 53 patients died. Aminopenicillins, first-generation cephalosporins, and--when prescribed alone--amoxicillin/clavulanate were not effective. Third-generation cephalosporins, most often used in combination with other antibiotics, were successful in 85% of cases. Fluoroquinolones--alone or in combination--cured all of 15 infections, with patients improving rapidly and becoming apyretic within 1-4 days. These agents therefore seem to constitute the best treatment.
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              Placebo-controlled double-blind evaluation of trimethoprim-sulfamethoxazole treatment of Yersinia enterocolitica gastroenteritis.

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                Author and article information

                Journal
                adp
                Archivos de Pediatría del Uruguay
                Arch. Pediatr. Urug.
                Sociedad Uruguaya de Pediatría (Montevideo, , Uruguay )
                0004-0584
                1688-1249
                December 2012
                : 83
                : 3
                : 185-188
                Affiliations
                [02] orgnameAsociación Española orgdiv1Departamento de Atención integral al niño y adolescente
                [01] Montevideo orgnameAsociación Española Uruguay carolinarocena@ 123456yahoo.com
                [03] orgnameAsociación Española orgdiv1Departamento de Atención integral al niño y adolescente orgdiv2Udelar
                Article
                S1688-12492012000300005 S1688-1249(12)08300305
                5ad9792e-b4e5-4662-828c-56c92d63cf61

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 15 May 2012
                : 26 July 2012
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 18, Pages: 4
                Product

                SciELO Uruguay

                Categories
                Caso Clínico

                YERSINIA ENTEROCOLITICA,APPENDICITIS,BACTEREMIA,ARTHRITIS,ILEITIS,APENDICITIS,BACTERIEMIA,ARTRITIS

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