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      Myelitis as a side effect of tofersen therapy in SOD1-associated ALS

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          Most cited references12

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          The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III).

          The ALS Functional Rating Scale (ALSFRS) is a validated rating instrument for monitoring the progression of disability in patients with amyotrophic lateral sclerosis (ALS). One weakness of the ALSFRS as originally designed was that it granted disproportionate weighting to limb and bulbar, as compared to respiratory, dysfunction. We have now validated a revised version of the ALSFRS, which incorporates additional assessments of dyspnea, orthopnea, and the need for ventilatory support. The Revised ALSFRS (ALSFRS-R) retains the properties of the original scale and shows strong internal consistency and construct validity. ALSFRS-R scores correlate significantly with quality of life as measured by the Sickness Impact Profile, indicating that the quality of function is a strong determinant of quality of life in ALS.
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            Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS

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              Genetic epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-analysis

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                Author and article information

                Contributors
                Peter.Reilich@med.uni-muenchen.de
                Journal
                J Neurol
                J Neurol
                Journal of Neurology
                Springer Berlin Heidelberg (Berlin/Heidelberg )
                0340-5354
                1432-1459
                9 December 2023
                9 December 2023
                2024
                : 271
                : 4
                : 2114-2118
                Affiliations
                [1 ]GRID grid.5252.0, ISNI 0000 0004 1936 973X, Present Address: Friedrich Baur Institute at the Department of Neurology, University Hospital, , LMU Munich, ; Ziemssenstr. 1, 80336 Munich, Germany
                [2 ]GRID grid.5252.0, ISNI 0000 0004 1936 973X, Present Address: Department of Neurology, University Hospital, , LMU Munich, ; Munich, Germany
                [3 ]Department of Neurology, University Clinic, University of Ulm, ( https://ror.org/032000t02) Ulm, Germany
                Author information
                http://orcid.org/0000-0002-2464-0681
                Article
                12130
                10.1007/s00415-023-12130-1
                10973064
                38066205
                5ad0d7e2-29c7-4575-b47c-1d90da12097f
                © The Author(s) 2023

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 25 September 2023
                : 20 November 2023
                : 21 November 2023
                Funding
                Funded by: Universitätsklinik München (6933)
                Categories
                Letter to the Editors
                Custom metadata
                © Springer-Verlag GmbH Germany, part of Springer Nature 2024

                Neurology
                Neurology

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