For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
21
views
94
references
 Top references
cited by
39
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      72
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Barrier integrity is central to the maintenance of healthy immunological homeostasis. Impaired skin barrier function is linked with enhanced allergen sensitization and the development of diseases such as atopic dermatitis (AD), which can precede the development of other allergic disorders, for example, food allergies and asthma. Epidemiological evidence indicates that children suffering from allergies have lower levels of dietary fibre-derived short-chain fatty acids (SCFA). Using an experimental model of AD-like skin inflammation, we report that a fermentable fibre-rich diet alleviates systemic allergen sensitization and disease severity. The gut-skin axis underpins this phenomenon through SCFA production, particularly butyrate, which strengthens skin barrier function by altering mitochondrial metabolism of epidermal keratinocytes and the production of key structural components. Our results demonstrate that dietary fibre and SCFA improve epidermal barrier integrity, ultimately limiting early allergen sensitization and disease development.

          The Graphical Abstract was designed using Servier Medical Art images ( https://smart.servier.com).

          Related collections

          Most cited references94

          • Record: found
          • Abstract: found
          • Article: not found

          featureCounts: an efficient general purpose program for assigning sequence reads to genomic features.

          Y. Liao, G K Smyth, W Shi (2014)
          Next-generation sequencing technologies generate millions of short sequence reads, which are usually aligned to a reference genome. In many applications, the key information required for downstream analysis is the number of reads mapping to each genomic feature, for example to each exon or each gene. The process of counting reads is called read summarization. Read summarization is required for a great variety of genomic analyses but has so far received relatively little attention in the literature. We present featureCounts, a read summarization program suitable for counting reads generated from either RNA or genomic DNA sequencing experiments. featureCounts implements highly efficient chromosome hashing and feature blocking techniques. It is considerably faster than existing methods (by an order of magnitude for gene-level summarization) and requires far less computer memory. It works with either single or paired-end reads and provides a wide range of options appropriate for different sequencing applications. featureCounts is available under GNU General Public License as part of the Subread (http://subread.sourceforge.net) or Rsubread (http://www.bioconductor.org) software packages.
          Article 0 comments Cited 8113 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Gene Expression Omnibus: NCBI gene expression and hybridization array data repository.

            R. Edgar (2002)
            The Gene Expression Omnibus (GEO) project was initiated in response to the growing demand for a public repository for high-throughput gene expression data. GEO provides a flexible and open design that facilitates submission, storage and retrieval of heterogeneous data sets from high-throughput gene expression and genomic hybridization experiments. GEO is not intended to replace in house gene expression databases that benefit from coherent data sets, and which are constructed to facilitate a particular analytic method, but rather complement these by acting as a tertiary, central data distribution hub. The three central data entities of GEO are platforms, samples and series, and were designed with gene expression and genomic hybridization experiments in mind. A platform is, essentially, a list of probes that define what set of molecules may be detected. A sample describes the set of molecules that are being probed and references a single platform used to generate its molecular abundance data. A series organizes samples into the meaningful data sets which make up an experiment. The GEO repository is publicly accessible through the World Wide Web at http://www.ncbi.nlm.nih.gov/geo.
            Article 0 comments Cited 2495 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Metabolites produced by commensal bacteria promote peripheral regulatory T cell generation

              Nicholas Arpaia, Clarissa Campbell, Xiying Fan … (2014)
              Intestinal microbes provide multicellular hosts with nutrients and confer resistance to infection. The delicate balance between pro- and anti-inflammatory mechanisms, essential for gut immune homeostasis, is affected by the composition of the commensal microbial community. Regulatory T (Treg) cells expressing transcription factor Foxp3 play a key role in limiting inflammatory responses in the intestine 1 . Although specific members of the commensal microbial community have been found to potentiate the generation of anti-inflammatory Treg or pro-inflammatory Th17 cells 2-6 , the molecular cues driving this process remain elusive. Considering the vital metabolic function afforded by commensal microorganisms, we hypothesized that their metabolic by-products are sensed by cells of the immune system and affect the balance between pro- and anti-inflammatory cells. We found that a short-chain fatty acid (SCFA), butyrate, produced by commensal microorganisms during starch fermentation, facilitated extrathymic generation of Treg cells. A boost in Treg cell numbers upon provision of butyrate was due to potentiation of extrathymic differentiation of Treg cells as the observed phenomenon was dependent upon intronic enhancer CNS1, essential for extrathymic, but dispensable for thymic Treg cell differentiation 1, 7 . In addition to butyrate, de novo Treg cell generation in the periphery was potentiated by propionate, another SCFA of microbial origin capable of HDAC inhibition, but not acetate, lacking this activity. Our results suggest that bacterial metabolites mediate communication between the commensal microbiota and the immune system, affecting the balance between pro- and anti-inflammatory mechanisms.
              Article 0 comments Cited 1248 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Aurélien Trompette: aurelien.trompette@chuv.ch
                Benjamin J. Marsland:
                ORCID: http://orcid.org/0000-0003-1457-3160
                benjamin.marsland@monash.edu
                Journal
                Journal ID (nlm-ta): Mucosal Immunol
                Journal ID (iso-abbrev): Mucosal Immunol
                Title: Mucosal Immunology
                Publisher: Nature Publishing Group US (New York )
                ISSN (Print): 1933-0219
                ISSN (Electronic): 1935-3456
                Publication date (Electronic): 7 June 2022
                Publication date PMC-release: 7 June 2022
                Publication date (Print): 2022
                Volume: 15
                Issue: 5
                Pages: 908-926
                Affiliations
                [1 ]GRID grid.8515.9, ISNI 0000 0001 0423 4662, Division of Pulmonary Medicine, Department of Medicine, , Lausanne University Hospital (CHUV), University of Lausanne (UNIL), ; Lausanne, Switzerland
                [2 ]GRID grid.1002.3, ISNI 0000 0004 1936 7857, Department of Immunology and Pathology, Central Clinical School, , Monash University, ; Melbourne, VIC Australia
                [3 ]GRID grid.5379.8, ISNI 0000000121662407, Laboratory for Lipidomics and Lipid Biology, University of Manchester, Division of Pharmacy and Optometry, Faculty of Biology Medicine and Health, Manchester Academic Health Science Centre, , The University of Manchester, ; Manchester, M13 9PT UK
                [4 ]GRID grid.5333.6, ISNI 0000000121839049, Nestlé Institute of Health, EPFL innovation Park, ; Lausanne, Switzerland
                [5 ]GRID grid.1002.3, ISNI 0000 0004 1936 7857, Monash Bioinformatics Platform, , Monash University, ; Clayton, VIC Australia
                [6 ]Pneumologie, Clinic Cecil from Hirslanden, Lausanne, Switzerland
                Author information
                http://orcid.org/0000-0003-1457-3160
                Article
                Publisher ID: 524
                DOI: 10.1038/s41385-022-00524-9
                PMC ID: 9385498
                PubMed ID: 35672452
                SO-VID: 5a4f2ff0-49da-4d5a-8ea3-5a57368186e5
                Copyright © © The Author(s) 2022
                License:

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

                History
                Date received : 2 March 2022
                Date revision received : 6 April 2022
                Date accepted : 25 April 2022
                Categories
                Subject: Article
                Custom metadata
                issue-copyright-statement © Society for Mucosal Immunology 2022

                ScienceOpen disciplines: Immunology
                Data availability:
                ScienceOpen disciplines: Immunology

                Comments

                Comment on this article

                scite_

                Similar content72

                See all similar

                Cited by39

                See all cited by

                Most referenced authors1,656

                See all reference authors