Antifungal lock therapy: an eternal promise or an effective alternative therapeutic approach?

Abstract

Each year, millions of central venous catheter insertions are performed in intensive care units worldwide. The usage of these indwelling devices is associated with a high risk of bacterial and fungal colonization, leading to the development of microbial consortia, namely biofilms. These sessile structures provide fungal cells with resistance to the majority of antifungals, environmental stress and host immune responses. Based on different guidelines, colonized/infected catheters should be removed and changed immediately in the case of Candida‐related central line infections. However, catheter replacement is not feasible for all patient populations. An alternative therapeutic approach may be antifungal lock therapy, which has received high interest, especially in the last decade. This review summarizes the published Candida‐related in vitro, in vivo data and case studies in terms of antifungal lock therapy. The number of clinical studies remains limited and further studies are needed for safe implementation of the antifungal lock therapy into clinical practice.

Abstract

Significance and impact of the study: Antifungal lock therapy is a promising alternative therapeutic approach for the treatment of Candida‐related central line infections without catheter removal. This review summarizes the most relevant in vitro, in vivo and clinical data, published in the last two decades, regarded as antifungal lock therapy.