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      National implementation of multi‐parametric magnetic resonance imaging for prostate cancer detection – recommendations from a UK consensus meeting

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          Abstract

          Objectives

          To identify areas of agreement and disagreement in the implementation of multi‐parametric magnetic resonance imaging (mp MRI) of the prostate in the diagnostic pathway.

          Materials and Methods

          Fifteen UK experts in prostate mp MRI and/or prostate cancer management across the UK (involving nine NHS centres to provide for geographical spread) participated in a consensus meeting following the Research and Development Corporation and University of California‐Los Angeles ( UCLARAND) Appropriateness Method, and were moderated by an independent chair. The experts considered 354 items pertaining to who can request an mp MRI, prostate mp MRI protocol, reporting guidelines, training, quality assurance ( QA) and patient management based on mp MRI levels of suspicion for cancer. Each item was rated for agreement on a 9‐point scale. A panel median score of ≥7 constituted ‘agreement’ for an item; for an item to reach ‘consensus’, a panel majority scoring was required.

          Results

          Consensus was reached on 59% of items (208/354); these were used to provide recommendations for the implementation of prostate mp MRI in the UK. Key findings include prostate mp MRI requests should be made in consultation with the urological team; mp MRI scanners should undergo QA checks to guarantee consistently high diagnostic quality scans; scans should only be reported by trained and experienced radiologists to ensure that men with unsuspicious prostate mp MRI might consider avoiding an immediate biopsy.

          Conclusions

          Our consensus statements demonstrate a set of criteria that are required for the practical dissemination of consistently high‐quality prostate mp MRI as a diagnostic test before biopsy in men at risk.

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          Most cited references69

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          Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS): a paired validating confirmatory study

          Men with high serum prostate specific antigen usually undergo transrectal ultrasound-guided prostate biopsy (TRUS-biopsy). TRUS-biopsy can cause side-effects including bleeding, pain, and infection. Multi-parametric magnetic resonance imaging (MP-MRI) used as a triage test might allow men to avoid unnecessary TRUS-biopsy and improve diagnostic accuracy.
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            PI-RADS Prostate Imaging - Reporting and Data System: 2015, Version 2.

            The Prostate Imaging - Reporting and Data System Version 2 (PI-RADS™ v2) is the product of an international collaboration of the American College of Radiology (ACR), European Society of Uroradiology (ESUR), and AdMetech Foundation. It is designed to promote global standardization and diminish variation in the acquisition, interpretation, and reporting of prostate multiparametric magnetic resonance imaging (mpMRI) examination, and it is based on the best available evidence and expert consensus opinion. It establishes minimum acceptable technical parameters for prostate mpMRI, simplifies and standardizes terminology and content of reports, and provides assessment categories that summarize levels of suspicion or risk of clinically significant prostate cancer that can be used to assist selection of patients for biopsies and management. It is intended to be used in routine clinical practice and also to facilitate data collection and outcome monitoring for research.
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              ESUR prostate MR guidelines 2012

              The aim was to develop clinical guidelines for multi-parametric MRI of the prostate by a group of prostate MRI experts from the European Society of Urogenital Radiology (ESUR), based on literature evidence and consensus expert opinion. True evidence-based guidelines could not be formulated, but a compromise, reflected by “minimal” and “optimal” requirements has been made. The scope of these ESUR guidelines is to promulgate high quality MRI in acquisition and evaluation with the correct indications for prostate cancer across the whole of Europe and eventually outside Europe. The guidelines for the optimal technique and three protocols for “detection”, “staging” and “node and bone” are presented. The use of endorectal coil vs. pelvic phased array coil and 1.5 vs. 3 T is discussed. Clinical indications and a PI-RADS classification for structured reporting are presented. Key Points • This report provides guidelines for magnetic resonance imaging (MRI) in prostate cancer. • Clinical indications, and minimal and optimal imaging acquisition protocols are provided. • A structured reporting system (PI-RADS) is described.
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                Author and article information

                Contributors
                shonit.punwani@gmail.com
                Journal
                BJU Int
                BJU Int
                10.1111/(ISSN)1464-410X
                BJU
                Bju International
                John Wiley and Sons Inc. (Hoboken )
                1464-4096
                1464-410X
                05 June 2018
                July 2018
                : 122
                : 1 ( doiID: 10.1111/bju.2018.122.issue-1 )
                : 13-25
                Affiliations
                [ 1 ] Centre for Medical Imaging University College London Hospitals NHS Foundation Trust University College London London UK
                [ 2 ] Department of Urology Hertfordshire and Bedfordshire Urological Cancer Centre Lister Hospital Stevenage Hertfordshire UK
                [ 3 ] Division of Surgery and Interventional Science Faculty of Medical Sciences University College London Hospitals NHS Foundation Trust University College London London UK
                [ 4 ] Division of Surgery Department of Surgery and Cancer Imperial College London and Imperial Urology Imperial College Healthcare NHS Trust London UK
                [ 5 ] Department of Radiology University College London Hospitals NHS Foundation Trust University College London London UK
                [ 6 ] Department of Medical Physics University College London Hospitals NHS Foundation Trust University College London London UK
                [ 7 ] Department of Radiology Addenbrooke's Hospital and University of Cambridge Cambridge UK
                [ 8 ] School of Health and Related Research University of Sheffield Sheffield UK
                [ 9 ] Department of Radiology Freeman Hospital Newcastle upon Tyne UK
                [ 10 ] Department of Urology Addenbrooke's Hospital and University of Cambridge Cambridge UK
                [ 11 ] The Society and College of Radiographers London UK
                [ 12 ] Department of Urology NHS Lothian Western General Hospital Edinburgh UK
                [ 13 ] Prostate Cancer UK London UK
                [ 14 ] Department of Urology University College London Hospitals NHS Foundation Trust University College London London UK
                [ 15 ] Division of Cancer Research Ninewells Hospital Dundee UK
                [ 16 ] Paul Strickland Scanner Centre Mount Vernon Hospital Northwood Middlesex UK
                [ 17 ] Department of Academic Urology Royal Marsden Hospital Sutton Surrey UK
                [ 18 ] Department of Radiology Lister Hospital Stevenage Hertfordshire UK
                [ 19 ] Department of Radiology Greater Glasgow and Clyde NHS Trust Glasgow UK
                [ 20 ] Department of Radiology Royal Sussex County Hospital Brighton and Brighton and Sussex Medical School Brighton Sussex UK
                [ 21 ] Division of Cancer and Genetics School of Medicine Cardiff University Cardiff UK
                [ 22 ] London School of Hygiene and Tropical Medicine London UK
                [ 23 ] Division of Nuclear Medicine University College London Hospitals NHS Foundation Trust University College London London UK
                Author notes
                [*] [* ] Correspondence: Dr Shonit Punwani, Centre for Medical Imaging, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK.

                e‐mail: shonit.punwani@ 123456gmail.com

                Author information
                http://orcid.org/0000-0002-1014-0870
                Article
                BJU14361
                10.1111/bju.14361
                6334741
                29699001
                59877990-37e3-46fd-aa7a-d382837a814c
                © 2018 The Authors BJU International published by John Wiley & Sons Ltd on behalf of BJU International

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                Page count
                Figures: 2, Tables: 6, Pages: 13, Words: 9312
                Funding
                Funded by: Prostate Cancer UK
                Funded by: London Cancer
                Funded by: NHS National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care North Thames
                Funded by: NIHR Imperial Biomedical Research Centre
                Funded by: Wellcome Trust
                Funded by: NIHR University College London Hospitals
                Funded by: Cancer Research UK (CRUK) King’s College London (KCL)/University College London (UCL) Cancer Imaging Centre
                Funded by: NHS England
                Categories
                Review
                Guidelines
                Custom metadata
                2.0
                bju14361
                July 2018
                Converter:WILEY_ML3GV2_TO_NLMPMC version:version=5.5.4 mode:remove_FC converted:16.01.2019

                Urology
                consensus methods,multi‐parametric mri,prostate cancer,recommendations
                Urology
                consensus methods, multi‐parametric mri, prostate cancer, recommendations

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