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      Dignity neuroscience: universal rights are rooted in human brain science

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          Abstract

          Universal human rights are defined by international agreements, law, foreign policy, and the concept of inherent human dignity. However, rights defined on this basis can be readily subverted by overt and covert disagreements and can be treated as distant geopolitical events rather than bearing on individuals’ everyday lives. A robust case for universal human rights is urgently needed and must meet several disparate requirements: (1) a framework that resolves tautological definitions reached solely by mutual, revocable agreement; (2) a rationale that transcends differences in beliefs, creed, and culture; and (3) a personalization that empowers both individuals and governments to further human rights protections. We propose that human rights in existing agreements comprise five elemental types: (1) agency, autonomy, and self‐determination; (2) freedom from want; (3) freedom from fear; (4) uniqueness; and (5) unconditionality, including protections for vulnerable populations. We further propose these rights and protections are rooted in fundamental properties of the human brain. We provide a robust, empirical foundation for universal rights based on emerging work in human brain science that we term dignity neuroscience. Dignity neuroscience provides an empirical foundation to support and foster human dignity, universal rights, and their active furtherance by individuals, nations, and international law.

          Abstract

          We propose that human rights are deeply rooted in human brain science, which provides a novel evidentiary base informing the universality, scope, and content of human rights and their relationship to human dignity

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          Socioeconomic status and the developing brain.

          Childhood socioeconomic status (SES) is associated with cognitive achievement throughout life. How does SES relate to brain development, and what are the mechanisms by which SES might exert its influence? We review studies in which behavioral, electrophysiological and neuroimaging methods have been used to characterize SES disparities in neurocognitive function. These studies indicate that SES is an important predictor of neurocognitive performance, particularly of language and executive function, and that SES differences are found in neural processing even when performance levels are equal. Implications for basic cognitive neuroscience and for understanding and ameliorating the problems related to childhood poverty are discussed.
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            The effects of childhood maltreatment on brain structure, function and connectivity.

            Maltreatment-related childhood adversity is the leading preventable risk factor for mental illness and substance abuse. Although the association between maltreatment and psychopathology is compelling, there is a pressing need to understand how maltreatment increases the risk of psychiatric disorders. Emerging evidence suggests that maltreatment alters trajectories of brain development to affect sensory systems, network architecture and circuits involved in threat detection, emotional regulation and reward anticipation. This Review explores whether these alterations reflect toxic effects of early-life stress or potentially adaptive modifications, the relationship between psychopathology and brain changes, and the distinction between resilience, susceptibility and compensation.
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              Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex

              Systematic analyses of spatiotemporal gene expression trajectories during organogenesis have been challenging because diverse cell types at different stages of maturation and differentiation coexist in the emerging tissues. We identified discrete cell types as well as temporally and spatially restricted trajectories of radial glia maturation and neurogenesis in developing human telencephalon. These lineage-specific trajectories reveal the expression of neurogenic transcription factors in early radial glia and enriched activation of mammalian target of rapamycin signaling in outer radial glia. Across cortical areas, modest transcriptional differences among radial glia cascade into robust typological distinctions among maturing neurons. Together, our results support a mixed model of topographical, typological, and temporal hierarchies governing cell-type diversity in the developing human telencephalon, including distinct excitatory lineages emerging in rostral and caudal cerebral cortex.
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                Author and article information

                Contributors
                Tara_White@Brown.edu
                Journal
                Ann N Y Acad Sci
                Ann N Y Acad Sci
                10.1111/(ISSN)1749-6632
                NYAS
                Annals of the New York Academy of Sciences
                John Wiley and Sons Inc. (Hoboken )
                0077-8923
                1749-6632
                05 August 2021
                December 2021
                : 1505
                : 1 , Annals Reports ( doiID: 10.1111/nyas.v1505.1 )
                : 40-54
                Affiliations
                [ 1 ] Department of Behavioral and Social Sciences, School of Public Health Brown University Providence Rhode Island
                [ 2 ] Center for Alcohol and Addiction Studies Brown University Providence Rhode Island
                [ 3 ] Carney Institute for Brain Science Brown University Providence Rhode Island
                [ 4 ] University of Cambridge England Cambridge UK
                [ 5 ] Neuroscience Graduate Program Brown University Providence Rhode Island
                Author notes
                [*] [* ]Address for correspondence: Tara L. White, Department of Behavioral and Social Sciences, School of Public Health, Brown University, Box G‐S121‐5, 121 South Main St., Providence, RI 02912. Tara_White@ 123456Brown.edu

                Author information
                https://orcid.org/0000-0003-3395-0136
                https://orcid.org/0000-0003-0819-5124
                Article
                NYAS14670
                10.1111/nyas.14670
                9291326
                34350987
                59799325-5936-4a42-8e73-a3c660a6c5c2
                © 2021 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals LLC on behalf of New York Academy of Sciences

                This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

                History
                : 25 June 2021
                : 11 March 2021
                : 08 July 2021
                Page count
                Figures: 2, Tables: 2, Pages: 15, Words: 9814
                Funding
                Funded by: Clare Hall International Visiting Fellowship, University of Cambridge, England, U.K.
                Funded by: British Academy International Visiting Fellowship
                Funded by: Zimmerman Fund for Scientific Innovation Awards in Brain Science, Robert J. and Nancy D. Carney Institute for Brain Science
                Categories
                Nyasbiol3577
                Nyasneur1110
                Nyaspsyc7766
                Nyassoci9990
                Review
                Reviews
                Custom metadata
                2.0
                December 2021
                Converter:WILEY_ML3GV2_TO_JATSPMC version:6.1.7 mode:remove_FC converted:18.07.2022

                Uncategorized
                neuroscience,universal human rights,international law,public policy,sustainable development goals

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