Sleep-Cognition Hypothesis In maritime Pilots, what is the effect of long-term work-related poor sleep on cognition and amyloid accumulation in healthy middle-aged maritime pilots: methodology of a case–control study

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Introduction

Evidence indicates a bidirectional relationship between poor sleep and Alzheimer’s disease (AD). While AD may lead to disruption of normal sleep, poor sleep in itself may play a causal role in the development of AD by influencing the production and/or clearance of the amyloid-beta (Aβ) protein. This led to the hypothesis that extended periods (>10 years) of sleep loss could lead to Aβ accumulation with subsequent cognitive AD-related decline. This manuscript describes the methodology of the SCHIP study, a cohort study in maritime pilots that aims at investigating the relationship between prolonged work-related sleep loss, cognitive function and amyloid accumulation among healthy middle-aged maritime pilots, to test the hypothesis that prolonged sleep loss increases the risk of AD-related cognitive decline.

Methods

Our study sample consists of a group of healthy middle-aged maritime pilots (n=20), who have been exposed to highly irregular work schedules for more than 15 years. The maritime pilots will be compared to a group of healthy, age and education-matched controls (n=20) with normal sleep. Participants will complete 10 days of actigraphy (Actiwatch 2, Philips Respironics) combined with a sleep-wake diary. They will undergo one night of polysomnography, followed by comprehensive assessment of cognitive function. Additionally, participants will undergo amyloid positron emission tomography-CT to measure brain amyloid accumulation and MRI to investigate atrophy and vascular changes.

Analysis

All analyses will be performed using IBM SPSS V.20.0 (SPSS). We will perform independent samples t-tests to compare all outcome parameters.

Ethics and dissemination

The study protocol was approved by our institutional ethical review board (NL55712.091.16, file number 2016–2337) and will be performed according to Good Clinical Practice rules. Data and results will be published in 2020.

Related collections

Most cited references 13

Record: found
Abstract: found
Article: not found

Sleep quality and 1-year incident cognitive impairment in community-dwelling older adults.

Olivier Potvin, Dominique Lorrain, Hélène Forget … (2012)

To examine in cognitively intact older men and women the associations between subjective sleep quality and 1-yr incident cognitive impairment. Prospective cohort study. General community. 1,664 cognitively intact individuals age 65 to 96 years. Sleep quality at baseline was measured using the Pittsburgh Sleep Quality Index (PSQI). Cognitive functioning was assessed at baseline and 12 months later using the Mini-Mental State Examination (MMSE). Incident general cognitive impairment was defined according to a follow-up MMSE score below the 15(th) percentile according to normative data and of at least 2 points below baseline. General cognitive impairments were also separated into amnestic and nonamnestic subtypes according to MMSE delayed recall performance. Associations between sleep quality indicators at baseline and incident cognitive impairment were assessed by odds ratio (OR) adjusted for age, education, baseline MMSE score, psychotropic drug use, anxiety, depressive episodes, cardiovascular conditions, and chronic diseases. Results revealed that global PSQI score was significantly linked with incident cognitive impairment (OR 1.17, 95% confidence interval (CI) 1.05-1.30) in men, but not in women. In women, sleep disturbance score (OR 2.62, 95% CI 1.41-4.86) and long sleep duration (≥ 9 hr; OR 3.70, 95% CI 1.49-9.17) were associated with nonamnestic and amnestic incident cognitive impairment, respectively. In men, short sleep duration (≤ 5 hr; OR 4.95, 95% CI 1.72-14.27) and habitual sleep efficiency score (OR 1.94, 95% CI 1.42-2.66) were associated with amnestic and general incident cognitive impairment, respectively. Sleep quality in older adults should receive particular attention by clinicians because poor sleep quality can be an early sign of cognitive decline.

0 comments Cited 89 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Lifespan brain activity, β-amyloid, and Alzheimer's disease.

William Jagust, Elizabeth Mormino (2011)

Alzheimer's disease (AD) is the most common cause of progressive cognitive decline and dementia in adults. While the amyloid cascade hypothesis of AD posits an initiating role for the β-amyloid (Aβ) protein, there is limited understanding of why Aβ is deposited. A growing body of evidence based on in vitro, animal studies and human imaging work suggests that synaptic activity increases Aβ, which is deposited preferentially in multimodal brain regions that show continuous levels of heightened activation and plasticity across the lifespan. Imaging studies of people with genetic predispositions to AD are consistent with these findings, suggesting a mechanism whereby neural efficiency or cognitive reserve may diminish Aβ deposition. The aggregated findings unify observations from cellular and molecular studies with human cognitive neuroscience to reveal potential mechanisms of AD development. Copyright © 2011 Elsevier Ltd. All rights reserved.

0 comments Cited 80 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Sleep disturbance is associated with incident dementia and mortality.

Benjamin Rusak, Roxanne Sterniczuk, Kenneth Rockwood … (2013)

People with Alzheimer' s disease (AD) commonly complain of sleep disturbances, which are seen in a wide variety of conditions that become more common in late life. It is not known whether sleep-related symptoms are associated with AD independently of their association with other illnesses. Secondary analyses of sleep-related measures collected through the Survey of Health, Ageing and Retirement in Europe (SHARE; i.e., sleeping problems, fatigue, taking sleeping medication, and trouble sleeping or a change in pattern) were conducted on those who reported the absence of AD or dementia at baseline. A 'sleep disturbance index' (SDI) using sleep-related measures was created and compared to a frailty index reflecting overall health status. Each sleep measure independently predicted self-reported AD or dementia and mortality within ~4 years. Combined, the SDI was associated with an increased risk of developing AD or dementia (OR= 1.23, 95%CI = 1.11-1.36) and mortality (OR = 1.18, 95% CI = 1.12-1.24), and remained a strong factor for dementia when overall health status was added to the risk model (p = 0.054). These findings indicate that sleep disturbance may exist prior to the manifestation of other typical symptoms observed in AD (e.g., memory loss). Sleep-related questions may be useful for screening individuals at risk for dementia and may allow for the earlier detection of AD at the preclinical stage.

0 comments Cited 78 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Journal ID (nlm-ta): BMJ Open

Journal ID (iso-abbrev): BMJ Open

Journal ID (hwp): bmjopen

Journal ID (publisher-id): bmjopen

Title: BMJ Open

Publisher: BMJ Publishing Group (BMA House, Tavistock Square, London, WC1H 9JR )

ISSN (Electronic): 2044-6055

Publication date Collection: 2019

Publication date (Electronic): 27 June 2019

Volume: 9

Issue: 6

Electronic Location Identifier: e026992

Affiliations

[1 ] departmentGeriatric Medicine , Radboudumc , Nijmegen, The Netherlands

[2 ] Radboud Alzheimer Center , Nijmegen, The Netherlands

[3 ] Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center , Nijmegen, The Netherlands

[4 ] departmentNeurology , Radboudumc , Nijmegen, The Netherlands

[5 ] departmentRadiology and Nuclear Medicine , Academic Medical Center , Amsterdam, The Netherlands

[6 ] departmentRadiology and Nuclear Medicine , Radboudumc , Nijmegen, The Netherlands

[7 ] Vincent van Gogh Institute for Psychiatry , Venray, The Netherlands

[8 ] departmentMedical Psychology , Radboudumc , Nijmegen, The Netherlands

[9 ] departmentEindhoven Medtech Innovation Center , Eindhoven University of Technology , Eindhoven, The Netherlands

[10 ] Sleep Medicine Center Kempenhaeghe , Heeze, The Netherlands

Author notes

[Correspondence to ] Miss Jana Thomas; jana.thomas@ 123456radboudumc.nl

Author information

Jana Thomas http://orcid.org/0000-0002-8249-7369

Roy P C Kessels http://orcid.org/0000-0001-9500-9793

Article

Publisher ID: bmjopen-2018-026992

DOI: 10.1136/bmjopen-2018-026992

PMC ID: 6597630

PubMed ID: 31248923

SO-VID: 59790b87-0805-425e-bfbe-6ecd61202b85

License:

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

History

Date received : 01 October 2018

Date revision received : 21 May 2019

Date accepted : 05 June 2019

Funding

Funded by: FundRef http://dx.doi.org/10.13039/501100008398, Internationale Stichting Alzheimer Onderzoek;

Custom metadata

special-feature unlocked

ScienceOpen disciplines: Medicine

Keywords: alzheimer’s disease,amyloid accumulation,neurodegeneration,cognitive function,sleep

Data availability:

ScienceOpen disciplines: Medicine

Keywords: alzheimer’s disease, amyloid accumulation, neurodegeneration, cognitive function, sleep

Sleep-Cognition Hypothesis In maritime Pilots, what is the effect of long-term work-related poor sleep on cognition and amyloid accumulation in healthy middle-aged maritime pilots: methodology of a case–control study

Read this article at

Abstract

Introduction

Methods

Analysis

Ethics and dissemination

Related collections

Beyond the Snore: Comprehensive Studies on Sleep Apnea

Most cited references 13

Sleep quality and 1-year incident cognitive impairment in community-dwelling older adults.

Lifespan brain activity, β-amyloid, and Alzheimer's disease.

Sleep disturbance is associated with incident dementia and mortality.

Author and article information

Journal

Affiliations

Author notes

Author information

Article

History

Funding

Categories

Custom metadata

Comments

Comment on this article

Similar content 412

Cited by 6

Most referenced authors 450