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      Knowledge towards Prevention and Early Detection of Chronic Kidney Disease and Associated Factors among Hypertensive Patients at a Chronic Illness Clinic of Jimma Town Public Hospitals

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          Abstract

          Background

          Morbidity and mortality due to chronic kidney disease are increasing among hypertensive patients in Sub-Saharan Africa. The majority of hypertensive patients with chronic kidney disease are not diagnosed at an early stage because of poor knowledge. However, to the best of our knowledge, there is no study conducted in Ethiopia about knowledge of hypertensive patients towards prevention and early detection of chronic kidney disease. Thus, the aim of this study was to assess knowledge towards prevention and early detection of chronic kidney disease and associated factors among hypertensive patients at Jimma town public hospitals, Ethiopia.

          Methods

          A hospital-based cross-sectional study was conducted among 332 hypertensive patients using an interviewer-administered questionnaire and medical record reviewing from April 5 to May 21, 2019. Study participants were selected using simple random sampling. Data were collected by using a standardized questionnaire. Data were entered into Epidata version 3.1 and analyzed by SPSS version 23. Descriptive statistics and bivariable and multivariable logistic regression were applied. To identify factors, a 95% confidence level and P value of less than 0.05 were considered.

          Results

          Over half (59.6%) were males, and the mean (±SD) age of participants was 54.92 (12.91) years. Among the total participants, more than half of them (47.9%) had good knowledge. Attending secondary education (AOR = 2.9, P = 0.014), higher education (AOR = 5.4, P = 0.001), working in private sectors (AOR = 4.3, P = 0.001), taking three and above drugs per day (AOR = 0.55, P = 0.016), and having a family history of kidney disease (AOR = 2.3, P = 0.012) were significantly associated with knowledge. Conclusion and Recommendation. Near to half of the study participants had good knowledge towards prevention and early detection of chronic kidney disease. Attending secondary education and above, working in private sectors, taking three and above drugs per day, and having a family history of kidney disease were independent predictors of knowledge. Hypertensive patients should be encouraged to be aware of risk factors of CKD, and health care providers should educate hypertensive patients about the prevention and early detection of chronic kidney disease.

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          Most cited references27

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          Hypertension awareness, treatment, and control in adults with CKD: results from the Chronic Renal Insufficiency Cohort (CRIC) Study.

          A low rate of blood pressure control has been reported in patients with chronic kidney disease (CKD). These data were derived from population-based samples with a low rate of CKD awareness. Cross-sectional. Data from the baseline visit of the Chronic Renal Insufficiency Cohort (CRIC) Study (n = 3,612) were analyzed. Participants with an estimated glomerular filtration rate of 20-70 mL/min/1.73 m(2) were identified from physician offices and review of laboratory databases. Prevalence and awareness of hypertension, treatment patterns, control rates, and factors associated with hypertension control. Following a standardized protocol, blood pressure was measured 3 times by trained staff, and hypertension was defined as systolic blood pressure > or =140 mm Hg and/or diastolic blood pressure > or =90 mm Hg and/or self-reported antihypertensive medication use. Patients' awareness and treatment of hypertension were defined using self-report, and 2 levels of hypertension control were evaluated: systolic/diastolic blood pressure or =4 antihypertensive medications, respectively. After multivariable adjustment, older patients, blacks, and those with higher urinary albumin excretion were less likely, whereas participants using angiotensin-converting enzyme inhibitors and angiotensin receptor blockers were more likely to have controlled their hypertension to <140/90 and <130/80 mm Hg. Data were derived from a single study visit. Despite almost universal hypertension awareness and treatment in this cohort of patients with CKD, rates of hypertension control were suboptimal. Copyright 2010 National Kidney Foundation, Inc. All rights reserved.
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            The epidemiology of chronic kidney disease in sub-Saharan Africa: a systematic review and meta-analysis.

            Amid rapid urbanisation, the HIV epidemic, and increasing rates of non-communicable diseases, people in sub-Saharan Africa are especially vulnerable to kidney disease. Little is known about the epidemiology of chronic kidney disease (CKD) in sub-Saharan Africa, so we did a systematic review and meta-analysis examining the epidemiology of the disease. We searched Medline, Embase, and WHO Global Health Library databases for all articles published through March 29, 2012, and searched the reference lists of retrieved articles. We independently reviewed each study for quality. We used the inverse-variance random-effects method for meta-analyses of the medium-quality and high-quality data and explored heterogeneity by comparing CKD burdens across countries, settings (urban or rural), comorbid disorders (hypertension, diabetes, HIV), CKD definitions, and time. Overall, we included 90 studies from 96 sites in the review. Study quality was low, with only 18 (20%) medium-quality studies and three (3%) high-quality studies. We noted moderate heterogeneity between the medium-quality and high-quality studies (n=21; I(2)=47·11%, p<0·0009). Measurement of urine protein was the most common method of determining the presence of kidney disease (62 [69%] studies), but the Cockcroft-Gault formula (22 [24%] studies) and Modification of Diet in Renal Disease formula (17 [19%] studies) were also used. Most of the studies were done in urban settings (83 [93%] studies) and after the year 2000 (57 [63%] studies), and we detected no significant difference in the prevalence of CKD between urban (12·4%, 95% CI 11-14) and rural (16·5%, 13·8-19·6) settings (p=0·474). The overall prevalence of CKD from the 21 medium-quality and high-quality studies was 13·9% (95% CI 12·2-15·7). In sub-Saharan Africa, CKD is a substantial health burden with risk factors that include communicable and non-communicable diseases. However, poor data quality limits inferences and draws attention to the need for more information and validated measures of kidney function especially in the context of the growing burden of non-communicable diseases. Duke University. Copyright © 2014 Stanifer et al. Open Access article distributed under the terms of CC BY-NC-ND. Published by .. All rights reserved.
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              Prevalence of hypertension in Ethiopia: a systematic meta-analysis

              Background Hypertension has been increasing in developing countries including Ethiopia. Other than smaller studies, there is no national prevalence study on hypertension in Ethiopia. These smaller studies reported varied prevalence of hypertension. This study is intended to summarize and pool the results of smaller region based studies to provide a national level estimate of the prevalence of hypertension. Methods The studies were identified through internet search using the data base of MEDLINE/PubMed, Google scholar, EMBASE, HINARI, Cochrane library and reference lists of previous prevalence studies. We also made manual searches to identify relevant articles. Descriptive information for the original studies is presented in a table and the quantitative results were presented in forest plots. The Cochrane Q test and I2 test statistic were used to test heterogeneity across studies. The Pooled estimate of prevalence of hypertension was computed by a random effects model. Results One hundred eight titles were identified through electronic searching using keywords. Of these, nine studies were meet the inclusion criteria. A random effect meta-analysis of the results from these 9 studies was conducted to provide an estimate of the prevalence of hypertension in the Ethiopian population. The analysis showed that the prevalence of hypertension among Ethiopian population was estimated to be 19.6 % (95 % CI: 13.7 %, 25.5 %). Subgroup analyses indicated that the prevalence of hypertension is higher in the urban population (23.7 %) than rural and urban combined (14.7 %). The prevalence of hypertension among males (20.6 %) and females (19.2 %) was similar. Conclusion This study found that the prevalence of hypertension in Ethiopia is increasing. This evidence suggests that attention has to be given to primary prevention of hypertension in the Ethiopian adult population, especially in the urban population by integrating it with health extension programs.
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                Author and article information

                Contributors
                Journal
                Biomed Res Int
                Biomed Res Int
                BMRI
                BioMed Research International
                Hindawi
                2314-6133
                2314-6141
                2020
                21 October 2020
                : 2020
                : 5969326
                Affiliations
                1Department of Nursing, School of Nursing and Midwifery, Wollo University, Dessie, Ethiopia
                2Department of Nursing, Jimma University, Ethiopia
                Author notes

                Academic Editor: Hiroshi Tanaka

                Author information
                https://orcid.org/0000-0002-8990-2646
                https://orcid.org/0000-0003-1001-7466
                https://orcid.org/0000-0003-1136-4101
                Article
                10.1155/2020/5969326
                7599397
                33145356
                5957235b-e860-4e9f-9601-98861bc3d882
                Copyright © 2020 Belachew Tegegne et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 28 July 2020
                : 28 September 2020
                : 13 October 2020
                Funding
                Funded by: Wollo University
                Categories
                Research Article

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