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      Metabolic Instruction of Immunity

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          Abstract

          Choices have consequences. Immune cells survey and migrate throughout the body and sometimes take residence in niche environments with distinct communities of cells, extracellular matrix, and nutrients that may differ from those in which they matured. Imbedded in immune cell physiology are metabolic pathways and metabolites that not only provide energy and substrates for growth and survival, but also instruct effector functions, differentiation, and gene expression. This review of immunometabolism will reference the most recent literature to cover the choices that environments impose on the metabolism and function of immune cells and highlight their consequences during homeostasis and disease.

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          Author and article information

          Journal
          0413066
          2830
          Cell
          Cell
          Cell
          0092-8674
          1097-4172
          17 April 2017
          04 May 2017
          04 May 2018
          : 169
          : 4
          : 570-586
          Affiliations
          [1 ]Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany
          [2 ]Division of Biology and Biomedical Sciences Immunology Program, Washington University School of Medicine, St. Louis, MO 63110, USA
          [3 ]Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
          Author notes
          Article
          PMC5648021 PMC5648021 5648021 nihpa866825
          10.1016/j.cell.2017.04.004
          5648021
          28475890
          589973e3-e4bd-46c4-a0ee-5405928d0cf9
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