Caloric restriction: is mammalian life extension linked to p53?

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Abstract

Caloric restriction, that is limiting food intake, is recognized in mammals as the best characterized and most reproducible strategy for extending lifespan, retarding physiological aging and delaying the onset of age-associated diseases. The aim of this mini review is to argue that p53 is the connection in the abilities of both the Sirt-1 pathway and the TOR pathway to impact on longevity of cells and organisms. This novel, lifespan regulating function of p53 may be evolutionarily more ancient than its relatively recent role in apoptosis and tumour suppression, and is likely to provide many new insights into lifespan modulation.

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Most cited references 142

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Sirtuin activators mimic caloric restriction and delay ageing in metazoans.

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Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the sirtuin family of NAD+-dependent deacetylases. Sirtuin activating compounds (STACs) can promote the survival of human cells and extend the replicative lifespan of yeast. Here we show that resveratrol and other STACs activate sirtuins from Caenorhabditis elegans and Drosophila melanogaster, and extend the lifespan of these animals without reducing fecundity. Lifespan extension is dependent on functional Sir2, and is not observed when nutrients are restricted. Together these data indicate that STACs slow metazoan ageing by mechanisms that may be related to caloric restriction.

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Author and article information

Journal

Journal ID (nlm-ta): Aging (Albany NY)

Journal ID (iso-abbrev): Aging (Albany NY)

Journal ID (publisher-id): ImpactJ

Title: Aging (Albany NY)

Publisher: Impact Journals LLC

ISSN (Electronic): 1945-4589

Publication date Collection: August 2012

Publication date (Electronic): 22 August 2012

Volume: 4

Issue: 8

Pages: 525-534

Affiliations

¹ Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, UK

² Department of Pharmaco-Biology, University of Calabria, 87036 Rende (CS), Italy

Author notes

Correspondence to: Paola Tucci, PhD; paola.tucci@ 123456unical.it

Article

DOI: 10.18632/aging.100481

PMC ID: 3461340

PubMed ID: 22983298

SO-VID: 587bfb85-ddb4-450a-bf90-7761a1eab723

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

History

Date received : 6 August 2012

Date accepted : 21 August 2012

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