Changes in Gonadotropin Secretion following Complete or Hemicastration in the Adult Rat

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Abstract

The effect of sham castration, hemicastration or complete castration on gonadotropin and testosterone secretion was studied in adult male rats. Untreated control rats were autopsied 1, 10, 20, 30 and 40 days following assignment to treatment groups. Sham-castrated controls were autopsied 1, 2 and 3 days after surgery. Complete and hemicastrates were autopsied 1, 2, 3, 10, 20, 30 and 40 days after surgery. Serum levels of both FSH and LH were elevated by 24 h postcastration and the levels of both gonadotropins continued to rise throughout the course of the experiment. Serum leyels of LH rose following hemicastration and remained above control values through day 30. Serum FSH levels were not significantly affected by hemicastration. Compensatory testicular hypertrophy was not observed in hemicastrated rats.

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Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1975

Publication date (Print): 1975

Publication date (Electronic): 21 November 2008

Volume: 6

Issue: 2

Pages: 71-77

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Department of Oral Biology, University of Manitoba, Winnipeg, Man.

Article

Publisher ID: 178664 Other ID: Horm Res 1975;6:71–77

DOI: 10.1159/000178664

PubMed ID: 1183932

SO-VID: 585e08bf-f460-43da-ab42-ddaba5ba092f

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Changes in Gonadotropin Secretion following Complete or Hemicastration in the Adult Rat

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Karger: Endocrinology

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