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      A superparamagnetic polymersome with extremely high T 2 relaxivity for MRI and cancer-targeted drug delivery

      , , , , ,
      Biomaterials
      Elsevier BV

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          Abstract

          Improving the relaxivity of magnetic resonance imaging (MRI) contrast agents is an important challenge for cancer theranostics. Herein we report the design, synthesis, characterization, theoretical analysis and in vivo tests of a superparamagnetic polymersome as a new MRI contrast agent with extremely high T2 relaxivity (611.6 mM-1s-1). First, a noncytotoxic cancer-targeting polymersome is synthesized based on a biodegradable diblock copolymer, folic acid-poly(l-glutamic acid)-block-poly(ε-caprolactone) [FA-PGA-b-PCL]. Then, ultra-small superparamagnetic iron oxide nanoparticles (SPIONs) are in situ generated in the hydrophilic PGA coronas of polymersomes to afford magnetic polymersomes. The in vivo MRI assay revealed prominent negative contrast enhancement of magnetic polymersomes at a very low Fe dose of 0.011 mmol/kg. Moreover, this cancer-targeting magnetic polymersome can effectively encapsulate and deliver anticancer drug to inhibit the tumor growth, demonstrating promising theranostic applications in biomedicine.

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          Author and article information

          Journal
          Biomaterials
          Biomaterials
          Elsevier BV
          01429612
          January 2017
          January 2017
          : 114
          : 23-33
          Article
          10.1016/j.biomaterials.2016.10.027
          27837682
          585c7e5b-b737-48e7-8749-4b6f771488ff
          © 2017

          https://www.elsevier.com/tdm/userlicense/1.0/

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