Efficacy of the MAGE-A3 cancer immunotherapeutic as adjuvant therapy in patients with resected MAGE-A3-positive non-small-cell lung cancer (MAGRIT): a randomised, double-blind, placebo-controlled, phase 3 trial.

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Abstract

Fewer than half of the patients with completely resected non-small-cell lung cancer (NSCLC) are cured. Since the introduction of adjuvant chemotherapy in 2004, no substantial progress has been made in adjuvant treatment. We aimed to assess the efficacy of the MAGE-A3 cancer immunotherapeutic in surgically resected NSCLC.

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Journal

Journal ID (iso-abbrev): Lancet Oncol.

Title: The Lancet. Oncology

ISSN (Electronic): 1474-5488

ISSN (Print): 1470-2045

Publication date (Electronic): Jun 2016

Volume: 17

Issue: 6

Affiliations

[1 ] Respiratory Oncology Unit, Department of Respiratory Medicine, University Hospital KU Leuven, Leuven, Belgium. Electronic address: johan.vansteenkiste@uzleuven.be.

[2 ] Yonsei University College of Medicine, Seoul, South Korea.

[3 ] North Estonian Regional Hospital, Oncology Department, Tallinn, Estonia.

[4 ] Oncology Unit of Thymic Cancer, Rare Tumors and Sarcomas, Milan, Italy.

[5 ] Department of Thoracic Surgery, Zakopane, Poland.

[6 ] National Cancer Center, Goyang-si Kyunggi-do, South Korea.

[7 ] Medical University of Gdansk, Gdansk, Poland.

[8 ] Hyogo Cancer Center, Akashi City, Hyogo, Japan.

[9 ] Athens Medical Centre, Marousi, Greece.

[10 ] Kanagawa Cancer Center, Yokohama City, Japan.

[11 ] Department of Pneumology and Thoracic Surgery, Prague, Czech Republic.

[12 ] Shizuoka Cancer Center, Tokyo, Japan.

[13 ] Aichi Cancer Center Hospital 1-1, Aichi, Japan.

[14 ] Pulmonary Clinic, G Papanikolaou General Hospital of Thessaloniki, Aristotle University, Thessaloniki, Greece.

[15 ] Regional Oncology Dispensary Medgorodok, Chelyabinsk, Russia.

[16 ] Korányi National Institute of Pulmonology, Budapest, Hungary.

[17 ] Osaka City General Hospital, Osaka, Japan.

[18 ] Thoraxklinik Heidelberg gGmbH, Heidelberg, Germany.

[19 ] Oslo University Hospital, Rikshospitalet, Oslo, Norway.

[20 ] University Hospital of South Manchester, Manchester, UK.

[21 ] Hospital Central de Asturias, Oviedo, Spain.

[22 ] Shanghai Chest Hospital, Shanghai, China.

[23 ] The First Affiliated Hospital of Guangzhou Medical College, Guangzhou, China.

[24 ] Arnaud de Villeneuve Hospital, Montpellier, France.

[25 ] GSK Vaccines, Rixensart, Belgium.

[26 ] Joan and Sanford I Weill Medical College of Cornell University, New York, NY, USA.

Article

Publisher Item ID: S1470-2045(16)00099-1

DOI: 10.1016/S1470-2045(16)00099-1

PubMed ID: 27132212

SO-VID: 56bbf13f-3cc7-4b96-9673-359d8e153dfb

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