Polyfunctional T-cells and effector memory phenotype are associated with active TB in HIV-infected patients.

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Abstract

Polyfunctional T-cells associate with chronic viral infection control while their involvement in tuberculosis (TB) is unclear. We evaluated TB-specific polyfunctional T-cell response and memory status in antiretroviral treatment (ART)-naïve HIV-infected patients from a low TB-endemic country.

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Journal

Journal ID (iso-abbrev): J. Infect.

Title: The Journal of infection

ISSN (Electronic): 1532-2742

ISSN (Print): 0163-4453

Publication date (Electronic): Dec 2014

Volume: 69

Issue: 6

Affiliations

[1 ] Translational Research Unit, Department of Epidemiology and Preclinical Research, "L. Spallanzani" National Institute for Infectious Diseases (INMI), IRCCS, Via Portuense 292, 00149 Rome, Italy.

[2 ] Clinical Department, INMI, Rome, Italy.

[3 ] Department of Epidemiology and Preclinical Research, INMI, Rome, Italy.

[4 ] Translational Research Unit, Department of Epidemiology and Preclinical Research, "L. Spallanzani" National Institute for Infectious Diseases (INMI), IRCCS, Via Portuense 292, 00149 Rome, Italy. Electronic address: delia.goletti@inmi.it.

Article

Publisher Item ID: S0163-4453(14)00187-X

DOI: 10.1016/j.jinf.2014.06.009

PubMed ID: 24975174

SO-VID: 56992f9b-c4b3-47a6-bb3c-ea599573604e

History

Keywords: HIV,LTBI,Phenotype,Polyfunctional,Tuberculosis

Data availability:

Keywords: HIV, LTBI, Phenotype, Polyfunctional, Tuberculosis

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