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Plk1: unexpected roles in DNA replication.

Publication date: 2013-10-31

Keywords: Cell Cycle Proteins, metabolism, Centrosome, Humans, Protein-Serine-Threonine Kinases, Proteins, Proto-Oncogene Proteins

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Abstract

FOR20, a conserved centrosomal protein, is essential for Plk1 to localize to the centrosome during the S phase and regulate DNA replication. The absence of either Plk1 or FOR20 can stall the cell cycle by a previously unknown intra-S phase centrosomal checkpoint.

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PubMed ID:: 24042259

PMC ID:: 3817549

DOI:: 10.1038/cr.2013.130

ScienceOpen disciplines: Chemistry

Keywords: Cell Cycle Proteins,metabolism,Centrosome,Humans,Protein-Serine-Threonine Kinases,Proteins,Proto-Oncogene Proteins

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ScienceOpen disciplines: Chemistry

Keywords: Cell Cycle Proteins, metabolism, Centrosome, Humans, Protein-Serine-Threonine Kinases, Proteins, Proto-Oncogene Proteins

Plk1: unexpected roles in DNA replication.

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Journal of Circulating Biomarkers

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