TOPGEAR: A Randomized, Phase III Trial of Perioperative ECF Chemotherapy with or Without Preoperative Chemoradiation for Resectable Gastric Cancer: Interim Results from an International, Intergroup Trial of the AGITG, TROG, EORTC and CCTG.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Postoperative chemoradiation and perioperative chemotherapy using epirubicin/cisplatin/5-fluorouracil (ECF) represent two standards of care for resectable gastric cancer. In the TOPGEAR (Trial Of Preoperative therapy for Gastric and Esophagogastric junction AdenocaRcinoma) trial, we hypothesized that adding preoperative chemoradiation to perioperative ECF will improve survival; however, the safety and feasibility of preoperative chemoradiation have yet to be determined.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Ann. Surg. Oncol.

Title: Annals of surgical oncology

Publisher: Springer Nature

ISSN (Electronic): 1534-4681

ISSN (Print): 1068-9265

Publication date (Electronic): Aug 2017

Volume: 24

Issue: 8

Affiliations

[1 ] Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. Trevor.Leong@petermac.org.

[2 ] Upper Gastrointestinal and Soft Tissue Unit, School of Medicine, Princess Alexandra Hospital, University of Queensland, Woolloongabba, QLD, Australia.

[3 ] Radiation Oncology, University Hospitals Leuven, Department of Oncology, KU Leuven, Leuven, Belgium.

[4 ] Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

[5 ] NHMRC Clinical Trials Centre, University of Sydney, Camperdown, NSW, Australia.

[6 ] School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.

[7 ] Faculty of Medical and Health Sciences, University of Auckland, Grafton, Auckland, New Zealand.

[8 ] North West Cancer Centre, NEMSC, Tamworth, NSW, Australia.

[9 ] TROG Cancer Research, c/o Calvary Mater Newcastle, HRMC, Waratah, NSW, Australia.

[10 ] University Cancer Center Leipzig (UCCL), University Medicine Leipzig, Leipzig, Germany.

[11 ] Mount Sinai Hospital, Toronto, ON, Canada.

[12 ] Toronto General Hospital, Toronto, ON, Canada.

[13 ] Princess Margaret Hospital, Toronto, ON, Canada.

Article

Publisher Item ID: 10.1245/s10434-017-5830-6

DOI: 10.1245/s10434-017-5830-6

PubMed ID: 28337660

SO-VID: 564fd257-0a76-4f6c-9063-949b08ff8a42

History

Data availability:

Comments

Comment on this article

scite_

Cited by 77

See all cited by