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      From Plant to Patient: A Historical Perspective and Review of Selected Medicinal Plants in Dermatology

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          Abstract

          Skin conditions are a common health concern faced by patients of all ages. For thousands of years, plants have been used to treat various skin conditions, including acne, vitiligo, and psoriasis, to name a few. Today, with increasing patient preference for natural therapies, modern medicine is now more than ever incorporating age-old knowledge of herbal remedies useful in treating skin conditions into modern-day treatments. This review covers various plant-derived therapeutics (polyphenon E [sincatechins], psoralen, salicylic acid, anthralin, podophyllotoxin, and Filsuvez [birch triterpenes, oleogel-S10]) that have demonstrated scientific evidence of clinical efficacy for dermatologic disorders. The discovery, composition, history of use, and current uses in dermatology are summarized for each botanical ingredient.

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          Natural Products as Sources of New Drugs from 1981 to 2014.

          David J Newman, Gordon M Cragg (2016)
          This contribution is a completely updated and expanded version of the four prior analogous reviews that were published in this journal in 1997, 2003, 2007, and 2012. In the case of all approved therapeutic agents, the time frame has been extended to cover the 34 years from January 1, 1981, to December 31, 2014, for all diseases worldwide, and from 1950 (earliest so far identified) to December 2014 for all approved antitumor drugs worldwide. As mentioned in the 2012 review, we have continued to utilize our secondary subdivision of a "natural product mimic", or "NM", to join the original primary divisions and the designation "natural product botanical", or "NB", to cover those botanical "defined mixtures" now recognized as drug entities by the U.S. FDA (and similar organizations). From the data presented in this review, the utilization of natural products and/or their novel structures, in order to discover and develop the final drug entity, is still alive and well. For example, in the area of cancer, over the time frame from around the 1940s to the end of 2014, of the 175 small molecules approved, 131, or 75%, are other than "S" (synthetic), with 85, or 49%, actually being either natural products or directly derived therefrom. In other areas, the influence of natural product structures is quite marked, with, as expected from prior information, the anti-infective area being dependent on natural products and their structures. We wish to draw the attention of readers to the rapidly evolving recognition that a significant number of natural product drugs/leads are actually produced by microbes and/or microbial interactions with the "host from whence it was isolated", and therefore it is considered that this area of natural product research should be expanded significantly.
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            Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea.

            R Ruch, S. Cheng, J E Klaunig (1989)
            An antioxidant fraction of Chinese green tea (green tea antioxidant; GTA), containing several catechins, has been previously shown to inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor promotion in mouse skin. In the present study, GTA was shown to have antioxidative activity toward hydrogen peroxide (H2O2) and the superoxide radical (O2-). GTA also prevented oxygen radical and H2O2-induced cytotoxicity and inhibition of intercellular communication in cultured B6C3F1 mouse hepatocytes and human keratinocytes (NHEK cells). GTA (0.05-50 micrograms/ml) prevented the killing of hepatocytes (measured by lactate dehydrogenase release) by paraquat (1-10 mM) and glucose oxidase (0.8-40 micrograms/ml) in a concentration-dependent fashion. GTA (50 micrograms/ml) also prevented the inhibition of hepatocyte intercellular communication by paraquat (5 mM), glucose oxidase (0.8 micrograms/ml), and phenobarbital (500 micrograms/ml). In addition, GTA (50 micrograms/ml) prevented the inhibition of intercellular communication in human keratinocytes by TPA (100 ng/ml). Cytotoxicity and inhibition of intercellular communication, two possible mechanisms by which tumor promoters may produce their promoting effects were therefore prevented by GTA. The inhibition of these two effects of pro-oxidant compounds may suggest a mechanism by which GTA inhibits tumor promotion in vivo.
            Article 0 comments Cited 330 times – based on 0 reviews     Review now
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              Sexually transmitted diseases treatment guidelines, 2015.

              Kimberly Workowski, Gail A Bolan (2015)
              These guidelines for the treatment of persons who have or are at risk for sexually transmitted diseases (STDs) were updated by CDC after consultation with a group of professionals knowledgeable in the field of STDs who met in Atlanta on April 30-May 2, 2013. The information in this report updates the Sexually Transmitted Diseases Treatment Guidelines, 2010 (MMWR Recomm Rep 2010;59 [No. RR-12]). These updated guidelines discuss 1) alternative treatment regimens for Neisseria gonorrhoeae; 2) the use of nucleic acid amplification tests for the diagnosis of trichomoniasis; 3) alternative treatment options for genital warts; 4) the role of Mycoplasma genitalium in urethritis/cervicitis and treatment-related implications; 5) updated HPV vaccine recommendations and counseling messages; 6) the management of persons who are transgender; 7) annual testing for hepatitis C in persons with HIV infection; 8) updated recommendations for diagnostic evaluation of urethritis; and 9) retesting to detect repeat infection. Physicians and other health-care providers can use these guidelines to assist in the prevention and treatment of STDs.
              Article 0 comments Cited 294 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Cassandra L. Quave
                Journal
                Journal ID (nlm-ta): JID Innov
                Journal ID (iso-abbrev): JID Innov
                Title: JID Innovations
                Publisher: Elsevier
                ISSN (Electronic): 2667-0267
                Publication date PMC-release: 25 October 2024
                Publication date Collection: January 2025
                Publication date (Electronic): 25 October 2024
                Volume: 5
                Issue: 1
                Electronic Location Identifier: 100321
                Affiliations
                [1 ]Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, USA
                [2 ]Laboratory of Microbiology, Center of Excellence, Baku State University, Baku, Azerbaijan
                [3 ]ICESCO Biomedical Materials Department, Baku State University, Baku, Azerbaijan
                [4 ]Morehouse School of Medicine, Atlanta, Georgia, USA
                Author notes
                [∗ ]Correspondence: Cassandra L. Quave, Department of Dermatology and Center for the Study of Human Health, Emory University, 615 Michael Street, Whitehead 105L, Atlanta, Georgia 30322, USA. cquave@ 123456emory.edu
                Article
                Publisher Item ID: S2667-0267(24)00069-9 Publisher ID: 100321
                DOI: 10.1016/j.xjidi.2024.100321
                PMC ID: 11625147
                PubMed ID: 39651343
                SO-VID: 56481454-bd9f-41dc-bab3-45ccd68563d0
                Copyright © © 2024 Published by Elsevier Inc. on behalf of the Society for Investigative Dermatology.
                License:

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                Date received : 31 May 2024
                Date revision received : 3 October 2024
                Date accepted : 6 October 2024
                Categories
                Subject: Review

                Keywords: anthralin,medicinal plants,podophyllotoxin,polyphenon e,salicylic acid
                Data availability:
                Keywords: anthralin, medicinal plants, podophyllotoxin, polyphenon e, salicylic acid

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