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Abstract
Brassinosteroids regulate plant growth and development through a protein complex that
includes the leucine-rich repeat receptor-like protein kinase (LRR-RLK) brassinosteroid-insensitive
1 (BRI1). Activation tagging was used to identify a dominant genetic suppressor of
bri1, bak1-1D (bri1-associated receptor kinase 1-1Dominant), which encodes an LRR-RLK,
distinct from BRI1. Overexpression of BAK1 results in elongated organ phenotypes,
while a null allele of BAK1 displays a semidwarfed phenotype and has reduced sensitivity
to brassinosteroids (BRs). BAK1 is a serine/threonine protein kinase, and BRI1 and
BAK1 interact in vitro and in vivo. Expression of a dominant-negative mutant allele
of BAK1 causes a severe dwarf phenotype, resembling the phenotype of null bri1 alleles.
These results indicate BAK1 is a component of BR signaling.