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      Vagal nerve stimulation prevents reperfusion injury through inhibition of opening of mitochondrial permeability transition pore independent of the bradycardiac effect.

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          Abstract

          In spite of recent advances in coronary interventional therapy, reperfusion injury is still considered to be a major problem in patients undergoing surgical procedures, such as bypass grafting. Here we demonstrate a novel therapeutic strategy against ischemia-reperfusion injury: vagally mediated prevention of reperfusion-induced opening of mitochondrial permeability transition pore.

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          Author and article information

          Journal
          J Thorac Cardiovasc Surg
          The Journal of thoracic and cardiovascular surgery
          Elsevier BV
          1097-685X
          0022-5223
          Jan 2009
          : 137
          : 1
          Affiliations
          [1 ] Department of Cardiovascular Control, Kochi Medical School, Nankoku, Kochi, Japan.
          Article
          S0022-5223(08)01404-9
          10.1016/j.jtcvs.2008.08.020
          19154929
          55aff62c-0e7c-4cda-aeea-dcf33fda8da0
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