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      Centrioles, centrosomes, and cilia in health and disease.

      1 ,
      Cell
      Elsevier BV

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          Abstract

          Centrioles are barrel-shaped structures that are essential for the formation of centrosomes, cilia, and flagella. Here we review recent advances in our understanding of the function and biogenesis of these organelles, and we emphasize their connection to human disease. Deregulation of centrosome numbers has long been proposed to contribute to genome instability and tumor formation, whereas mutations in centrosomal proteins have recently been genetically linked to microcephaly and dwarfism. Finally, structural or functional centriole aberrations contribute to ciliopathies, a variety of complex diseases that stem from the absence or dysfunction of cilia.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          1097-4172
          0092-8674
          Nov 13 2009
          : 139
          : 4
          Affiliations
          [1 ] Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland. erich.nigg@unibas.ch
          Article
          S0092-8674(09)01362-2
          10.1016/j.cell.2009.10.036
          19914163
          551b9447-3b59-433b-9d9e-e45361b65e78
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