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      Functional hydrogel coatings

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          Abstract

          Hydrogels—natural or synthetic polymer networks that swell in water—can be made mechanically, chemically and electrically compatible with living tissues. There has been intense research and development of hydrogels for medical applications since the invention of hydrogel contact lenses in 1960. More recently, functional hydrogel coatings with controlled thickness and tough adhesion have been achieved on various substrates. Hydrogel-coated substrates combine the advantages of hydrogels, such as lubricity, biocompatibility and anti-biofouling properties, with the advantages of substrates, such as stiffness, toughness and strength. In this review, we focus on three aspects of functional hydrogel coatings: (i) applications and functions enabled by hydrogel coatings, (ii) methods of coating various substrates with different functional hydrogels with tough adhesion, and (iii) tests to evaluate the adhesion between functional hydrogel coatings and substrates. Conclusions and outlook are given at the end of this review.

          Abstract

          The emerging topic of functional hydrogel coatings are reviewed from three aspects: functions and applications of hydrogel coatings, methods of preparing hydrogel coatings with strong adhesion, and tests to evaluate the adhesion.

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          Most cited references135

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          Designing hydrogels for controlled drug delivery

          Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery and have found clinical use. Hydrogels can provide spatial and temporal control over the release of various therapeutic agents, including small-molecule drugs, macromolecular drugs and cells. Owing to their tunable physical properties, controllable degradability and capability to protect labile drugs from degradation, hydrogels serve as a platform in which various physiochemical interactions with the encapsulated drugs control their release. In this Review, we cover multiscale mechanisms underlying the design of hydrogel drug delivery systems, focusing on physical and chemical properties of the hydrogel network and the hydrogel-drug interactions across the network, mesh, and molecular (or atomistic) scales. We discuss how different mechanisms interact and can be integrated to exert fine control in time and space over the drug presentation. We also collect experimental release data from the literature, review clinical translation to date of these systems, and present quantitative comparisons between different systems to provide guidelines for the rational design of hydrogel delivery systems.
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            Hydrogels for tissue engineering.

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              Hydrogel ionotronics

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                Author and article information

                Contributors
                Journal
                Natl Sci Rev
                Natl Sci Rev
                nsr
                National Science Review
                Oxford University Press
                2095-5138
                2053-714X
                February 2021
                05 October 2020
                05 October 2020
                : 8
                : 2
                : nwaa254
                Affiliations
                Center for X-Mechanics, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province and Department of Engineering Mechanics, Zhejiang University , Hangzhou 310027, China
                State Key Laboratory of Fluid Power and Mechatronic System, Zhejiang University , Hangzhou 310027, China
                Applied Mechanics and Structure Safety Key Laboratory of Sichuan Province, School of Mechanics and Engineering, Southwest Jiaotong University , Chengdu 610031, China
                Center for X-Mechanics, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province and Department of Engineering Mechanics, Zhejiang University , Hangzhou 310027, China
                State Key Laboratory of Fluid Power and Mechatronic System, Zhejiang University , Hangzhou 310027, China
                John A. Paulson School of Engineering and Applied Sciences, Kavli Institute for Bionano Science and Technology, Harvard University , Cambridge, MA 02138, USA
                Center for X-Mechanics, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province and Department of Engineering Mechanics, Zhejiang University , Hangzhou 310027, China
                Author notes
                Corresponding author. E-mail: yangw@ 123456zju.edu.cn
                Article
                nwaa254
                10.1093/nsr/nwaa254
                8288423
                34691578
                54cdda45-1914-4cc2-b65b-426c2b2fbd52
                © The Author(s) 2020. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 08 March 2020
                : 22 September 2020
                : 23 September 2020
                Page count
                Pages: 19
                Funding
                Funded by: National Natural Science Foundation of China, DOI 10.13039/501100001809;
                Award ID: 11525210
                Funded by: Fundamental Research Funds for the Central Universities, DOI 10.13039/501100012226;
                Award ID: 91748209
                Funded by: National Science Foundation, DOI 10.13039/100000001;
                Award ID: 2020XZZX005–02
                Categories
                Materials Science
                Review
                AcademicSubjects/MED00010
                AcademicSubjects/SCI00010

                hydrogel coatings,coating methods,coating tests,adhesion,hydrogel applications

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