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Abstract
Deciphering the molecular basis of esophageal cancer metastasis requires adequate
experimental models. Epithelial-mesenchymal transition (EMT) is the hallmark of tumor
metastasis. As a promoter of the malignant progression of esophageal cancer, epidermal
growth factor (EGF) has been shown to induce EMT in several cell lines. In this study
we examined the effects of EGF on esophageal carcinoma EC109 cells. We found that
EGF at high concentration induced the cells to undergo morphological change, exhibit
higher invasive and metastatic potential, as well as change in the expression of lineage
markers. This EMT model might facilitate mechanistic studies of esophageal cancer
metastasis.
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