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Abstract
Increasing evidence suggests that antagonistic interactions between specific subtypes
of adenosine and dopamine receptors in the basal ganglia are involved in the motor
depressant effects of adenosine receptor agonists and the motor stimulant effects
of adenosine receptor antagonists, such as caffeine. The GABAergic striatopallidal
neurons are regulated by interacting adenosine A2A and dopamine D2 receptors. On the
other hand, the GABAergic striatonigral and striatoentopeduncular neurons seem to
be regulated by interacting adenosine A1 and dopamine D1 receptors. Furthermore, behavioural
studies have revealed interactions between adenosine A2A and dopamine D1 receptors
that occur at the network level. These adenosine-dopamine receptor-receptor interactions
might offer new therapeutic leads for basal ganglia disorders.