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      Making the Complicated Simple: A Minimizing Carrier Strategy on Innovative Nanopesticides

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          Highlights

          • Nanopesticides with minimizing carrier were prepared through prodrug molecular design and molecular self-assembly.

          • Nanopesticides with minimizing carrier are expected to solve the environmental risks caused by the unrestricted introduction of nanomaterials.

          • Future development and challenges of nanopesticides with minimizing carrier.

          Supplementary Information

          The online version contains supplementary material available at 10.1007/s40820-024-01413-5.

          Abstract

          The flourishing progress in nanotechnology offers boundless opportunities for agriculture, particularly in the realm of nanopesticides research and development. However, concerns have been raised regarding the human and environmental safety issues stemming from the unrestrained use of non-therapeutic nanomaterials in nanopesticides. It is also important to consider whether the current development strategy of nanopesticides based on nanocarriers can strike a balance between investment and return, and if the complex material composition genuinely improves the efficiency, safety, and circularity of nanopesticides. Herein, we introduced the concept of nanopesticides with minimizing carriers (NMC) prepared through prodrug design and molecular self-assembly emerging as practical tools to address the current limitations, and compared it with nanopesticides employing non-therapeutic nanomaterials as carriers (NNC). We further summarized the current development strategy of NMC and examined potential challenges in its preparation, performance, and production. Overall, we asserted that the development of NMC systems can serve as the innovative driving force catalyzing a green and efficient revolution in nanopesticides, offering a way out of the current predicament.

          Supplementary Information

          The online version contains supplementary material available at 10.1007/s40820-024-01413-5.

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          Most cited references84

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          Differentially charged nanoplastics demonstrate distinct accumulation in Arabidopsis thaliana

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            Beyond molecules: self-assembly of mesoscopic and macroscopic components.

            Self-assembly is a process in which components, either separate or linked, spontaneously form ordered aggregates. Self-assembly can occur with components having sizes from the molecular to the macroscopic, provided that appropriate conditions are met. Although much of the work in self-assembly has focused on molecular components, many of the most interesting applications of self-assembling processes can be found at larger sizes (nanometers to micrometers). These larger systems also offer a level of control over the characteristics of the components and over the interactions among them that makes fundamental investigations especially tractable.
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              A critical evaluation of nanopesticides and nanofertilizers against their conventional analogues

              Among a wide range of possible applications of nanotechnology in agriculture, there has been a particular interest in developing novel nanoagrochemicals. While some concerns have been expressed regarding altered risk profile of the new products, many foresee a great potential to support the necessary increase in global food production in a sustainable way. A critical evaluation of nanoagrochemicals against conventional analogues is essential to assess the associated benefits and risks. In this assessment, recent literature was critically analysed to determine the extent to which nanoagrochemicals differ from conventional products. Our analysis was based on 78 published papers and shows that median gain in efficacy relative to conventional products is about 20-30%. Environmental fate of agrochemicals can be altered by nanoformulations, but changes may not necessarily translate in a reduction of the environmental impact. Many studies lacked nano-specific quality assurance and adequate controls. Currently, there is no comprehensive study in the literature that evaluates efficacy and environmental impact of nanoagrochemicals under field conditions. This is a crucial knowledge gap and more work will thus be necessary for a sound evaluation of the benefits and new risks that nanoagrochemicals represent relative to existing products.
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                Author and article information

                Contributors
                qlhuang@ippcaas.cn
                caoys@cau.edu.cn
                caolidong@caas.cn
                Journal
                Nanomicro Lett
                Nanomicro Lett
                Nano-Micro Letters
                Springer Nature Singapore (Singapore )
                2311-6706
                2150-5551
                14 May 2024
                14 May 2024
                December 2024
                : 16
                : 193
                Affiliations
                [1 ]GRID grid.464356.6, ISNI 0000 0004 0499 5543, State Key Laboratory for Biology of Plant Diseases and Insect Pests , , Institute of Plant Protection, Chinese Academy of Agricultural Sciences, ; Beijing, 100193 People’s Republic of China
                [2 ]College of Plant Protection, China Agricultural University, ( https://ror.org/04v3ywz14) Beijing, 100193 People’s Republic of China
                [3 ]GRID grid.216938.7, ISNI 0000 0000 9878 7032, State Key Laboratory of Element-Organic Chemistry, Department of Chemical Biology, College of Chemistry, , Nankai University, ; Tianjin, 300071 People’s Republic of China
                Article
                1413
                10.1007/s40820-024-01413-5
                11093950
                38743342
                534d7e63-c81e-4152-8b15-9b3176edc8aa
                © The Author(s) 2024

                Open Access This article is licenced under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third-party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 23 February 2024
                : 7 April 2024
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                © Shanghai Jiao Tong University 2024

                nanopesticides,green agrochemicals,self-assembly,nanomaterial safety,sustainable development strategies

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