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Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer (KEYNOTE-355): a randomised, placebo-controlled, double-blind, phase 3 clinical trial
Javier Cortes ,
David W Cescon ,
Hope S Rugo ,
Zbigniew Nowecki ,
Seock-Ah Im ,
Mastura Md Yusof ,
Carlos Gallardo ,
Oleg Lipatov ,
Carlos H Barrios ,
Esther Holgado ,
Hiroji Iwata ,
Norikazu Masuda ,
Marco Torregroza Otero ,
Erhan Gokmen ,
Sherene Loi ,
Zifang Guo ,
Jing Zhao ,
Gursel Aktan ,
Vassiliki Karantza ,
Peter Schmid ,
Fein Luis ,
Gomez Abuin Gonzalo ,
Kaen Diego ,
Kowalwszyn Ruben ,
Molina Matias ,
Varela Mirta ,
Baron-Hay Sally ,
Begbie Stephen ,
Clingan Philip ,
Loi Sherene ,
Sabanathan Dhanusha ,
Gombos Andrea ,
Taylor Donatienne ,
Barrios Carlos ,
Brust Leandro ,
Costa Fabiano ,
de Freitas Junior Ruffo ,
Hegg Roberto ,
Lacerda Domicio Carvalho ,
Lissa Fernando Cezar Toniazzi ,
Rocha Roberto Odebrecht ,
Scalabrini Neto Antonio Orlando ,
Silva Felipe ,
Cescon David ,
Charpentier Danielle ,
Ferrario Cristiano ,
Song Xinni ,
Yu Joanne ,
Acevedo Alejandro ,
Gallardo Carlos ,
Salas Claudio ,
Sanchez Cesar ,
Yanez Eduardo ,
Gomez Diaz Alvaro ,
Sanchez Jesus ,
Holeckova Petra ,
Kral Zdenek ,
Melichar Bohuslav ,
Petrakova Katarina ,
Prausova Jana ,
Glavicic Vesna ,
Jakobsen Erik ,
Jensen Jeanette ,
Linnet Soren ,
Lorincz Tamas ,
Bonnefoi Herve ,
Desmoulins Isabelle ,
Goncalves Anthony ,
Hardy-Bessard Anne-Claire ,
Teixeira Luis ,
Blohmer Jens-Uwe ,
Fasching Peter ,
Forstmeyer Dirk ,
Harbeck Nadia ,
Huober Jens ,
Kaczerowsky Flores de Sousa Anna ,
Kurbacher Christian ,
Loibl Sibylle ,
Lueftner Diana ,
Park-Simon Tjoung-Won ,
Schumann Raquel Von ,
Wimberger Pauline ,
Chow Louis ,
Kwong Ava ,
Ngan Kai Cheong Roger ,
Arkosy Peter ,
Csoszi Tibor ,
Kahan Zsuzsanna ,
Landherr Laszlo ,
Mahr Karoly ,
Rubovszky Gabor ,
Crown John ,
Kelly Catherine ,
O'Reilly Seamus ,
Cinieri Saverio ,
DAlessio Antonietta ,
Ricevuto Enrico ,
Aruga Tomoyuki ,
Fujii Takaaki ,
Inoue Kenichi ,
Ishikawa Takashi ,
Ito Yoshinori ,
Iwasa Tsutomu ,
Iwata Hiroji ,
Kosaka Yoshimasa ,
Matsumoto Koji ,
Miyoshi Yasuo ,
Mukai Hirofumi ,
Nakamura Seigo ,
Niikura Naoki ,
Ohtani Shoichiro ,
Osaki Akihiko ,
Sagara Yasuaki ,
Suzuki Eiji ,
Takahashi Masato ,
Tanabe Yuko ,
Tamura Kenji ,
Tsugawa Koichiro ,
Watanabe Junichiro ,
Yamamoto Naohito ,
Yamamoto Yutaka ,
Yamauchi Teruo ,
Bustam Anita ,
Md Yusof Mastura ,
Gomez Villanueva Angel ,
Juarez Ramiro Alejandro ,
Martinez Rodriguez Jorge ,
Morales-Vasquez Flavia ,
Reyes Contreras Jessica ,
Beelen Karin ,
Tjan-Heijnen Vivianne ,
Porter David ,
Chmielowska Ewa ,
Nowakowska-Zajdel Ewa ,
Nowecki Zbigniew ,
Radecka Barbara ,
Streb Joanna ,
Szczylik Cezary ,
Tarnawski Rafal ,
Zurawski Bogdan ,
Arkhipov Alexander ,
Fadeeva Natalia ,
Lipatov Oleg ,
Meshcheryakov Andrey ,
Moiseyenko Vladimir ,
Mukhametshina Guzel ,
Ahn Jin Hee ,
Im Seock-Ah ,
Lee Keun Seok ,
Park Kwong Hwa ,
Park Yeon Hee ,
Bermejo de las Heras Begona ,
Cortes Javier ,
Cruz Jurado Josefina ,
de la Cruz Merino Luis ,
Garcia Saenz Jose ,
Gion Maria ,
Holgado Esther ,
Zamora Adelantado Esther ,
Liu Chien-Ting ,
Liu Mei-Ching ,
Huang Chiun-Sheng ,
Tsao Chao-Jung ,
Tseng Ling-Ming ,
Arslan Cagatay ,
Basaran Gul ,
Cicin Irfan ,
Gokmen Erhan ,
Gunduz Seyda ,
Molinas Mandel Nil ,
Ozguroglu Mustafa ,
Ozyilkan Ozgur ,
Yavuz Sinan ,
Chan Steve ,
Graham Janine ,
MacPherson Iain ,
Schmid Peter ,
Turner Nicholas ,
Tuthill Mark ,
Twelves Christopher ,
Wheatley Duncan ,
Adamchuk Hryhoriy ,
Berzoy Oleksandr ,
Bondarenko Igor ,
Kolesnik Oleksii ,
Kolesnik Olena ,
Komisarenko Hanna ,
Kryzhanivska Anna ,
Leshchenko Iurii ,
Nasonova Alla ,
Otchenash Natalya ,
Ponomarova Olga ,
Rusyn Andrii ,
Shevnya Sergii ,
Shparyk Yaroslav ,
Trukhin Dmytro ,
Ursol Grygorii ,
Vynnychenko Ihor ,
Blau Sibel ,
Chaudhry Madhu ,
Chung Michael ,
Cobb Patrick ,
Cole Scott ,
Diamond Jennifer ,
Gogineni Keerthi ,
Hargis Jeffrey ,
Hoskins Kent ,
Irvin William ,
Loutfi Randa ,
Lu Janice ,
Mena Raul ,
Moore Susan ,
Nanda Rita ,
Oliff Ira ,
Omene Coral ,
Panella Timothy ,
Panwalkar Amit ,
Patson Brian ,
Rugo Hope ,
Rybalova Irina ,
Schleider Michael ,
Siegel Robert ,
Simon Michael ,
Stampleman Laura ,
Sumrall Bradley ,
Tsai Michaela ,
Valdes-Albini Frances
December 2020
December 2020
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
<p class="first" id="d2887405e344">Pembrolizumab monotherapy showed durable antitumour
activity and manageable safety
in patients with metastatic triple-negative breast cancer. We aimed to examine whether
the addition of pembrolizumab would enhance the antitumour activity of chemotherapy
in patients with metastatic triple-negative breast cancer.
</p>