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Abstract
The nucleotide (nt) sequences of the Sc3 and Sc4 genes of the filamentous fungus Schizophyllum
commune, and the deduced amino acid (aa) sequences, were determined; moreover, the
previously published sequence for the Sc1 gene [Dons et al., EMBO J. 3 (1984) 2101-2106]
was corrected. All three independently isolated genes were found to have similar structures
and nt sequences of their coding regions. At the aa level the homology is 43-62% (63-69%
in the C-terminal parts of the proteins), the hydrophobic aa predominate and the hydrophobicity
patterns are similar. All three proteins contain leader sequences and eight cysteines
among about 110 aa, conserved at the same positions. Yet these genes are differentially
regulated: Sc1 and Sc4 are only expressed at high levels in fruiting dikaryons, whereas
Sc3 is highly expressed in both monokaryons and dikaryons, independent from fruiting.