Cytoplasmic ends of tetraspanin 7 harbour epitopes recognised by autoantibodies in type 1 diabetes.

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Abstract

The beta cell protein tetraspanin 7 is a target of autoantibodies in individuals with type 1 diabetes. The aim of this study was to identify autoantibody epitope-containing regions and key residues for autoantibody binding.

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Journal

Journal ID (iso-abbrev): Diabetologia

Title: Diabetologia

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1432-0428

ISSN (Print): 0012-186X

Publication date (Electronic): May 2019

Volume: 62

Issue: 5

Affiliations

[1 ] DFG-Centre for Regenerative Therapies Dresden, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 105, 01307, Dresden, Germany.

[2 ] Institute of Diabetes Research, Helmholtz Zentrum München, Munich, Germany.

[3 ] Forschergruppe Diabetes, Technische Universität München, Klinikum Rechts der Isar, Munich, Germany.

[4 ] Forschergruppe Diabetes e.V. at Helmholtz Zentrum München, Munich, Germany.

[5 ] DFG-Centre for Regenerative Therapies Dresden, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 105, 01307, Dresden, Germany. ezio.bonifacio@tu-dresden.de.

[6 ] Paul Langerhans Institute Dresden, Helmholtz Centre Munich, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. ezio.bonifacio@tu-dresden.de.

Article

Publisher Item ID: 10.1007/s00125-019-4832-2

DOI: 10.1007/s00125-019-4832-2

PubMed ID: 30789994

SO-VID: 52376e61-3e93-4d1f-a033-951d9e754072

History

Keywords: Tetraspanin 7,Autoantibodies,Epitopes,Glima 38,Type 1 diabetes mellitus

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Keywords: Tetraspanin 7, Autoantibodies, Epitopes, Glima 38, Type 1 diabetes mellitus

Cytoplasmic ends of tetraspanin 7 harbour epitopes recognised by autoantibodies in type 1 diabetes.

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