17β-estradiol prevents cardiac diastolic dysfunction by stimulating mitochondrial function: a preclinical study in a mouse model of a human hypertrophic cardiomyopathy mutation.

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Abstract

We investigated the effect of ovariectomy (OVX) and 17β-estradiol (E2) replacement on both mitochondrial and myocardial function in cTnT-Q92 transgenic mice generated by cardiac-restricted expression of a human hypertrophic cardiomyopathy (HCM) mutation.

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Author and article information

Journal

Journal ID (iso-abbrev): J. Steroid Biochem. Mol. Biol.

Title: The Journal of steroid biochemistry and molecular biology

Publisher: Elsevier BV

ISSN (Electronic): 1879-1220

ISSN (Print): 0960-0760

Publication date (Electronic): Mar 2015

Volume: 147

Affiliations

[1 ] Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, China.

[2 ] Department of Radiology, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 737 N Michigan Ave., 16th Floor, Chicago, USA.

[3 ] Clinical Laboratory of Zhongke, Beijing, China.

[4 ] Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, China. Electronic address: qsbfw@sina.com.

Article

Publisher Item ID: S0960-0760(14)00317-3

DOI: 10.1016/j.jsbmb.2014.12.011

PubMed ID: 25541436

SO-VID: 5220f3d6-ff74-4b86-a2ec-143fd1868323

History

Keywords: Energy metabolism,Estrogen replacement,Hypertrophic cardiomyopathy

Data availability:

Keywords: Energy metabolism, Estrogen replacement, Hypertrophic cardiomyopathy

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