Dashing Decades of Defeat: Long Anticipated Advances in the First-line Treatment of Extensive-Stage Small Cell Lung Cancer.

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Abstract

Small cell lung cancer (SCLC) is an exceptionally lethal subtype of lung cancer. For patients with extensive-stage (ES) disease, which is the majority of patients, platinum-doublet chemotherapy has been the standard of care for decades. Dozens of phase III trials have failed to improve survival over standard platinum plus etoposide. Recent results, however, have met with long-overdue success. This manuscript reviews the new standards of care for ES-SCLC.

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Author and article information

Journal

Journal ID (iso-abbrev): Curr Oncol Rep

Title: Current oncology reports

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1534-6269

ISSN (Print): 1523-3790

Publication date (Electronic): February 07 2020

Volume: 22

Issue: 2

Affiliations

[1 ] Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC, 20007, USA.

[2 ] Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC, 20007, USA. stephen.v.liu@gunet.georgetown.edu.

Article

Publisher Item ID: 10.1007/s11912-020-0887-y

DOI: 10.1007/s11912-020-0887-y

PubMed ID: 32034529

SO-VID: 51f42cc6-f0c2-4a10-8f93-398140b21b09

History

Keywords: Atezolizumab,Clinical trials,Durvalumab,Extensive-stage,Immunotherapy,SCLC,Small cell lung cancer

Data availability:

Keywords: Atezolizumab, Clinical trials, Durvalumab, Extensive-stage, Immunotherapy, SCLC, Small cell lung cancer

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