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      Three-Year Outcomes With the Absorb Bioresorbable Scaffold : Individual-Patient-Data Meta-Analysis From the ABSORB Randomized Trials

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          Abstract

          The Absorb bioresorbable vascular scaffold (BVS) completely resorbs within 3 years after coronary artery implantation. The safety and effectiveness of BVS through this critical 3-year period have not been characterized.

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          Most cited references35

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          Comparison of an everolimus-eluting bioresorbable scaffold with an everolimus-eluting metallic stent for the treatment of coronary artery stenosis (ABSORB II): a 3 year, randomised, controlled, single-blind, multicentre clinical trial.

          No medium-term data are available on the random comparison between everolimus-eluting bioresorbable vascular scaffolds and everolimus-eluting metallic stents. The study aims to demonstrate two mechanistic properties of the bioresorbable scaffold: increase in luminal dimensions as a result of recovered vasomotion of the scaffolded vessel.
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            Everolimus-Eluting Bioresorbable Scaffolds for Coronary Artery Disease.

            In patients with coronary artery disease who receive metallic drug-eluting coronary stents, adverse events such as late target-lesion failure may be related in part to the persistent presence of the metallic stent frame in the coronary-vessel wall. Bioresorbable vascular scaffolds have been developed to attempt to improve long-term outcomes.
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              Long-Term Safety of Drug-Eluting and Bare-Metal Stents: Evidence From a Comprehensive Network Meta-Analysis.

              Previous meta-analyses have investigated the relative safety and efficacy profiles of different types of drug-eluting stents (DES) and bare-metal stents (BMS); however, most prior trials in these meta-analyses reported follow-up to only 1 year, and as such, the relative long-term safety and efficacy of these devices are unknown. Many recent studies have now reported extended follow-up data.
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                Author and article information

                Journal
                Circulation
                Circulation
                Ovid Technologies (Wolters Kluwer Health)
                0009-7322
                1524-4539
                January 30 2018
                January 30 2018
                : 137
                : 5
                : 464-479
                Affiliations
                [1 ]New York–Presbyterian Hospital/Columbia University Medical Center, New York (Z.A.A., G.W.S.)
                [2 ]Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (Z.A.A., G.W.S.)
                [3 ]Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, China (R.G.)
                [4 ]Kyoto University Hospital, Japan (T.K.)
                [5 ]Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands (Y.O.)
                [6 ]The Christ Hospital, Heart and Vascular Center, Lindner Research Center, Cincinnati, OH (D.J.K.)
                [7 ]Cleveland Clinic, OH (S.G.E.)
                [8 ]Institut Cardiovasculaire Paris Sud, Massy, France (B.C.)
                [9 ]Abbott Vascular, Santa Clara, CA (M.-t.V., Z.Z., C.A.S.)
                [10 ]International Centre for Cardiovascular Health, Imperial College, London, UK (P.W.S.)
                Article
                10.1161/CIRCULATIONAHA.117.031843
                29089314
                51ad45a6-faef-47d4-9503-6c73818e533b
                © 2018
                History

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