CircRNAs: a new target for the diagnosis and treatment of digestive system neoplasms

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

A circRNA is a type of endogenous noncoding RNA that consists of a closed circular RNA molecule formed by reverse splicing; these RNAs are widely distributed in a variety of biological cells. In contrast to linear RNAs, circRNAs have no 5′ cap or 3′ poly(A) tail. They have a stable structure, a high degree of conservation, and high stability, and they are richly and specifically expressed in certain tissues and developmental stages. CircRNAs play a very important role in the occurrence and progression of malignant tumors. According to their origins, circRNAs can be divided into four types: exon-derived circRNAs (ecRNAs), intron-derived circRNAs (ciRNAs), circRNAs containing both exons and introns (EIciRNAs) and intergenic circRNAs. A large number of studies have shown that circRNAs have a variety of biological functions, participate in the regulation of gene expression and play an important role in the occurrence and progression of tumors. In this paper, the structure and function of circRNAs are reviewed, along with their biological role in malignant tumors of the digestive tract, in order to provide a reference for the diagnosis and treatment of digestive system neoplasms.

Related collections

Most cited references 90

Record: found
Abstract: found
Article: not found

Cancer statistics, 2020

Rebecca Siegel, Kimberly D Miller, Ahmedin Jemal (2020)

Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States and compiles the most recent data on population-based cancer occurrence. Incidence data (through 2016) were collected by the Surveillance, Epidemiology, and End Results Program; the National Program of Cancer Registries; and the North American Association of Central Cancer Registries. Mortality data (through 2017) were collected by the National Center for Health Statistics. In 2020, 1,806,590 new cancer cases and 606,520 cancer deaths are projected to occur in the United States. The cancer death rate rose until 1991, then fell continuously through 2017, resulting in an overall decline of 29% that translates into an estimated 2.9 million fewer cancer deaths than would have occurred if peak rates had persisted. This progress is driven by long-term declines in death rates for the 4 leading cancers (lung, colorectal, breast, prostate); however, over the past decade (2008-2017), reductions slowed for female breast and colorectal cancers, and halted for prostate cancer. In contrast, declines accelerated for lung cancer, from 3% annually during 2008 through 2013 to 5% during 2013 through 2017 in men and from 2% to almost 4% in women, spurring the largest ever single-year drop in overall cancer mortality of 2.2% from 2016 to 2017. Yet lung cancer still caused more deaths in 2017 than breast, prostate, colorectal, and brain cancers combined. Recent mortality declines were also dramatic for melanoma of the skin in the wake of US Food and Drug Administration approval of new therapies for metastatic disease, escalating to 7% annually during 2013 through 2017 from 1% during 2006 through 2010 in men and women aged 50 to 64 years and from 2% to 3% in those aged 20 to 49 years; annual declines of 5% to 6% in individuals aged 65 years and older are particularly striking because rates in this age group were increasing prior to 2013. It is also notable that long-term rapid increases in liver cancer mortality have attenuated in women and stabilized in men. In summary, slowing momentum for some cancers amenable to early detection is juxtaposed with notable gains for other common cancers.

0 comments Cited 9087 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

MicroRNAs: target recognition and regulatory functions.

David Bartel (2009)

MicroRNAs (miRNAs) are endogenous approximately 23 nt RNAs that play important gene-regulatory roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their posttranscriptional repression. This review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.

0 comments Cited 2438 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Circular RNAs are a large class of animal RNAs with regulatory potency.

Sebastian Memczak, Marvin Jens, Antigoni Elefsinioti … (2013)

Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.

0 comments Cited 2240 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Gang Wang:

ORCID: http://orcid.org/0000-0002-1186-4336

wgilu79@163.com

Journal

Journal ID (nlm-ta): Cell Death Dis

Journal ID (iso-abbrev): Cell Death Dis

Title: Cell Death & Disease

Publisher: Nature Publishing Group UK (London )

ISSN (Electronic): 2041-4889

Publication date (Electronic): 24 February 2021

Publication date PMC-release: 24 February 2021

Publication date Collection: February 2021

Volume: 12

Issue: 2

Electronic Location Identifier: 205

Affiliations

[1 ]GRID grid.412596.d, ISNI 0000 0004 1797 9737, Department of Pancreatic and Biliary Surgery, , The First Affiliated Hospital of Harbin Medical University, ; Harbin, Heilongjiang Province China

[2 ]GRID grid.412596.d, ISNI 0000 0004 1797 9737, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, , The First Affiliated Hospital of Harbin Medical University, ; Harbin, China

[3 ]GRID grid.413106.1, ISNI 0000 0000 9889 6335, Department of General Surgery, Peking Union Medical College Hospital, , Chinese Academy of Medial Sciences, ; Beijing, 100730 China

Author information

Jie Li http://orcid.org/0000-0003-2061-7430

Gang Wang http://orcid.org/0000-0002-1186-4336

Article

Publisher ID: 3495

DOI: 10.1038/s41419-021-03495-0

PMC ID: 7904779

PubMed ID: 33627631

SO-VID: 50d9c044-c921-473e-bc15-2151a4fb19f4

License:

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

History

Date received : 13 November 2020

Date revision received : 27 January 2021

Date accepted : 1 February 2021

Funding

Funded by: FundRef https://doi.org/10.13039/501100001809, National Natural Science Foundation of China (National Science Foundation of China);

Award ID: 82070657

Award Recipient : Gang Wang

Funded by: Applied Technology Research and Development Plan of Heilongjiang Province in China (NO: GA20C019).

Custom metadata

ScienceOpen disciplines: Cell biology

Keywords: tumour biomarkers,non-coding rnas

Data availability:

ScienceOpen disciplines: Cell biology

Keywords: tumour biomarkers, non-coding rnas

Comments

Comment on this article

scite_

Cited by 20

See all cited by

Most referenced authors 1,465

See all reference authors

- Version 1

CircRNAs: a new target for the diagnosis and treatment of digestive system neoplasms

Read this article at

Abstract

Related collections

Marine Life Science & Technology

Most cited references 90

Cancer statistics, 2020

MicroRNAs: target recognition and regulatory functions.

Circular RNAs are a large class of animal RNAs with regulatory potency.

Author and article information

Contributors

Journal

Affiliations

Author information

Article

History

Funding

Categories

Custom metadata

Comments

Comment on this article

Similar content 157

Cited by 20

Most referenced authors 1,465