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      Panax notoginseng saponin alleviates pulmonary fibrosis in rats by modulating the renin-angiotensin system

      Author(s): , , , , , , , ,
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      Journal: Journal of Ethnopharmacology
      Publisher: Elsevier BV

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          Abstract

          <p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d8059006e184">Pulmonary fibrosis (PF) is a chronic, progressive, and often fatal interstitial lung disease. Traditional Chinese medicine formulations and their active ingredients have shown potential in the treatment of PF. Panax notoginseng saponin (PNS) is extracted from the widely used traditional Chinese medicinal herb Panax notoginseng (Burkill) F. H. Chen, exhibiting therapeutic effects in pulmonary diseases treatment. </p>

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          Idiopathic pulmonary fibrosis.

          Luca Richeldi, Harold Collard, Mark G. Jones (2017)
          Idiopathic pulmonary fibrosis is a prototype of chronic, progressive, and fibrotic lung disease. Healthy tissue is replaced by altered extracellular matrix and alveolar architecture is destroyed, which leads to decreased lung compliance, disrupted gas exchange, and ultimately respiratory failure and death. In less than a decade, understanding of the pathogenesis and management of this disease has been transformed, and two disease-modifying therapies have been approved, worldwide. In this Seminar, we summarise the presentation, pathophysiology, diagnosis, and treatment options available for patients with idiopathic pulmonary fibrosis. This disease has improved understanding of the mechanisms of lung fibrosis, and offers hope that similar approaches will transform the management of patients with other progressive fibrotic lung diseases.
          Article 0 comments Cited 799 times – based on 0 reviews     Review now
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            Idiopathic Pulmonary Fibrosis

            Fernando J Martínez, David J. Lederer, Dan L Longo … (2018)
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              Simple method of estimating severity of pulmonary fibrosis on a numerical scale.

              T. Ashcroft, J. Simpson, V. Timbrell (1988)
              A continuous numerical scale for determining the degree of fibrosis in lung specimens was devised for correlation with other pulmonary variables such as lung function tests or mineral burden. Grading was scored on a scale from 0 to 8, using the average of microscope field scores. The system allows fibrosis to be measured in small samples of tissue (1 cm) which can provide a detailed description of the changes in a lung, currently not possible with most existing methods.
              Article 0 comments Cited 568 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Journal
                Title: Journal of Ethnopharmacology
                Abbreviated Title: Journal of Ethnopharmacology
                Publisher: Elsevier BV
                ISSN (Print): 03788741
                Publication date Created: January 2024
                Publication date (Print): January 2024
                Volume: 318
                Page: 116979
                Article
                DOI: 10.1016/j.jep.2023.116979
                PubMed ID: 37532070
                SO-VID: 50c88a58-2265-416e-bf27-13c538ad7e29
                Copyright © © 2024
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                https://www.elsevier.com/tdm/userlicense/1.0/

                http://creativecommons.org/licenses/by-nc-nd/4.0/

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