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      Cord factor producer Mycobacterium abscessus subsp. bolletii in asymptomatic immunocompetent host sputa samples

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          Abstract

          Abstract We report a case of Mycobacterium abscessus subsp. bolletii colonization in upper respiratory tract of an immunocompetent patient, who was misdiagnosed as tuberculosis by Acid Fast Bacilli (AFB) and cord factor formation observed directly from the sputa culture in liquid medium. This fact reflected a significant impact on the individual case’s life and showed the importance to identify the mycobacteria isolated from clinical sample at species level, and to determine the true implication of nontuberculous mycobacteria (NTM) detected in clinical samples.

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          Spontaneous reversion of Mycobacterium abscessus from a smooth to a rough morphotype is associated with reduced expression of glycopeptidolipid and reacquisition of an invasive phenotype.

          Xiuhua Pang, C. Rick Lyons, Thomas Byrd … (2006)
          Mycobacterium abscessus is an increasingly important cause of human disease; however, virulence determinants are largely uncharacterized. Previously, it was demonstrated that a rough, wild-type human clinical isolate (390R) causes persistent, invasive infection, while a smooth isogenic mutant (390S) has lost this capability. During serial passage of 390S, a spontaneous rough revertant was obtained, which was named 390V. This revertant regained the ability to cause persistent, invasive infection in human monocytes and the lungs of mice. Glycopeptidolipid (GPL), which plays a role in environmental colonization, was present in abundance in the cell wall of 390S, and was associated with sliding motility and biofilm formation. In contrast, a marked reduction in the amount of GPL in the cell wall of 390R and 390V was correlated with cord formation, a property associated with mycobacterial virulence. These results indicate that the ability to switch between smooth and rough morphologies may allow M. abscessus to transition between a colonizing phenotype and a more virulent, invasive form.
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            Fatal pulmonary infection due to multidrug-resistant Mycobacterium abscessus in a patient with cystic fibrosis.

            E Fiscarelli, P D'Argenio, F Ardito … (2001)
            We report a case of fatal pulmonary infection caused by Mycobacterium abscessus in a young patient with cystic fibrosis, who underwent bipulmonary transplantation after a 1-year history of severe lung disease. Fifteen days after surgery he developed septic fever with progressive deterioration in lung function. M. abscessus, initially isolated from a pleural fluid specimen, was then recovered from repeated blood samples, suggesting a disseminated nature of the mycobacterial disease. Drug susceptibility testing assay, performed on two sequential isolates of the microorganism, showed a pattern of multidrug resistance. Despite aggressive therapy with several antimycobacterial drugs, including clarithromycin, the infection persisted, and the patient died.
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              Construction of Mycobacterium abscessus defined glycopeptidolipid mutants: comparison of genetic tools.

              Halima Medjahed, Jean-Marc Reyrat (2009)
              Mycobacterium abscessus is a rapidly growing mycobacterial species that can be involved in pulmonary and disseminated infections in immunosuppressed or young cystic fibrosis patients. It is an emerging pathogen and has attracted recent attention due to the numerous cases of infection; furthermore, genomic tools have been developed for this species. Nevertheless, the study of this species has until now been limited to spontaneous variants. We report here a comparison of three different mutagenesis systems--the ts-sacB, the phage, and the recombineering systems--and show that there are important differences in their efficiency for the construction of allelic-exchange mutants. We show, using the mmpL4b gene of the glycopeptidolipid pathway as a target, that allelic-exchange mutants can be constructed with a reasonable efficiency (approximately 7%) using the recombineering system. These observations will facilitate genetic and cellular microbiology experiments involving the construction and use of well-defined mutants to study the virulence determinant of this emerging pathogen.
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                Author and article information

                Journal
                Journal ID (publisher-id): bjps
                Title: Brazilian Journal of Pharmaceutical Sciences
                Abbreviated Title: Braz. J. Pharm. Sci.
                Publisher: Universidade de São Paulo, Faculdade de Ciências Farmacêuticas (São Paulo, SP, Brazil )
                ISSN (Electronic): 2175-9790
                Publication date (Print and electronic): 2022
                Volume: 58
                Electronic Location Identifier: e19504
                Affiliations
                [1] orgnameState University of Maringá orgdiv1Department of Clinical Analysis and Biomedicine orgdiv2Laboratory of Medical Bacteriology Brazil
                Article
                Publisher ID: S1984-82502022000100617 Publisher ID: S1984-8250(22)05800000617
                DOI: 10.1590/s2175-97902022e19504
                SO-VID: 50823327-d401-47e2-957c-559027be64b5
                License:

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                Date accepted : 07 December 2019
                Date received : 05 August 2019
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 15, Pages: 0
                Product

                SciELO Brazil

                Categories
                Subject: Article

                Keywords: Molecular diagnosis,Nontuberculous mycobacteria,Tuberculosis,Diagnosis,Microscopy
                Data availability:
                Keywords: Molecular diagnosis, Nontuberculous mycobacteria, Tuberculosis, Diagnosis, Microscopy

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