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      Landiolol for managing atrial fibrillation in intensive care

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          Abstract

          Landiolol is an injectable ultrashort acting beta-blocker with high beta1 selectivity indicated for heart rate control of atrial fibrillation in the emergency and critical care setting. Accordingly, landiolol is associated with a significantly reduced risk of arterial hypotension and negative inotropic effects. Based on this particular profile along with the clinical experience in Japan for more than a decade landiolol represents a promising agent for the management of elevated heart rate and atrial fibrillation in intensive care patients even with catecholamine requirements. This article provides a review and perspective of landiolol for heart rate control in intensive care patients based on the current literature.

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          Most cited references39

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          Guidelines for Pharmacotherapy of Atrial Fibrillation (JCS 2013).

          (2014)
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            Long-term outcomes following development of new-onset atrial fibrillation during sepsis.

            New-onset atrial fibrillation (AF) is associated with adverse outcomes during a sepsis hospitalization; however, long-term outcomes following hospitalization with sepsis-associated new-onset AF are unclear.
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              Incidence, Predictors, and Outcomes of New-Onset Atrial Fibrillation in Critically Ill Patients with Sepsis. A Cohort Study.

              Patients admitted to intensive care units with sepsis are prone to developing cardiac dysrhythmias, most commonly atrial fibrillation.
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                Author and article information

                Journal
                Eur Heart J Suppl
                Eur Heart J Suppl
                ehjsupp
                European Heart Journal Supplements : Journal of the European Society of Cardiology
                Oxford University Press
                1520-765X
                1554-2815
                January 2018
                08 January 2018
                08 January 2018
                : 20
                : Suppl A , Landiolol: A new agent for Acute Rate Control in Atrial Fibrillation
                : A15-A18
                Affiliations
                [1 ]Department of Anaesthesiology, University Hospital of Greifswald, 17475 Greifswald, Germany
                [2 ]Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, A-6020 Innsbruck, Austria
                [3 ]Department of Critical Care and Anaesthesia, University Hospital Birmingham, Edgbaston, B15 2GW Birmingham, UK
                [4 ]Department of Anesthesiology and Intensive Care Medicine, University of Rome “La Sapienza”, Italy Policlinico Umberto I° Hospital, Viale del Policlinico 155, 00161 Rome, Italy
                Author notes
                Corresponding author. Tel: +49 (0)3834 865801, Fax: +49 (0)3834 865802, Email: Sebastian.Rehberg@ 123456uni-greifswald.de
                Article
                sux039
                10.1093/eurheartj/sux039
                5909768
                30188960
                506374e3-a9f0-4600-ba49-8e5797ff68cf
                Published on behalf of the European Society of Cardiology. © The Author 2018.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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                Page count
                Pages: 4
                Categories
                Articles

                landiolol,beta-blockers,atrial fibrillation,supraventricular arrhythmia,heart-rate control,sepsis,intensive care

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