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      Ethical concerns regarding heterologous COVID-19 vaccine administration

      letter
      a , b
      Human Vaccines & Immunotherapeutics
      Taylor & Francis
      Covid, vaccine, ethic, heterologous

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          Heterologous mRNA-based COVID-19 booster strategies: Comment

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            Evidence synthesis and pooled analysis of vaccine effectiveness for COVID-19 mRNA vaccine BNT162b2 as a heterologous booster after inactivated SARS-CoV-2 virus vaccines

            Introduction of primary COVID-19 vaccination has helped reduce severe disease and death caused by SARS-CoV-2 infection. Understanding the protection conferred by heterologous booster regimens informs alternative vaccination strategies that enable programmatic resilience and can catalyze vaccine confidence and coverage. Inactivated SARS-CoV-2 vaccines are among the most widely used vaccines worldwide. This review synthesizes the available evidence identified as of May 26, 2022, on the safety, immunogenicity, and effectiveness of a heterologous BNT162b2 (Pfizer-BioNTech) mRNA vaccine booster dose after an inactivated SARS-CoV-2 vaccine primary series, to help protect against COVID-19. Evidence showed that the heterologous BNT16b2 mRNA vaccine booster enhances immunogenicity and improves vaccine effectiveness against COVID-19, and no new safety concerns were identified with heterologous inactivated primary series with mRNA booster combinations.
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              Author and article information

              Journal
              Hum Vaccin Immunother
              Hum Vaccin Immunother
              Human Vaccines & Immunotherapeutics
              Taylor & Francis
              2164-5515
              2164-554X
              14 February 2024
              2024
              14 February 2024
              : 20
              : 1
              : 2313250
              Affiliations
              [a ]Private Academic and Editorial Consultant; , Bangkok, Thailand
              [b ]Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences Saveetha University India;
              Author notes
              CONTACT Somsri Wiwanitkit somsriwiwan@ 123456hotmail.com Private Academic and Editorial Consultant; , Bangkok 103300, Thailand.
              Author information
              https://orcid.org/0000-0003-1039-3728
              Article
              2313250
              10.1080/21645515.2024.2313250
              10878430
              38353267
              503373e7-0442-4c5d-9873-c1ff4e971c96
              © 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

              This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License ( http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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              Page count
              Figures: 0, References: 2, Pages: 1
              Categories
              Letter to the Editor
              Coronavirus

              Molecular medicine
              covid,vaccine,ethic,heterologous
              Molecular medicine
              covid, vaccine, ethic, heterologous

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