Chronic exposure to organophosphates: background and clinical picture

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Abstract

A male farmer in his forties from the Irish Republic was referred for an opinion on his mood swings and their possible relationship with organophosphate exposure. He had been regularly exposed to organophosphorus sheep dips for around 15 years prior to the assessment.

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Deliberate self harm in Sri Lanka: an overlooked tragedy in the developing world.

M. H. R. Sheriff, K Hawton, M Eddleston (1998)

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Increased risk of suicide with exposure to pesticides in an intensive agricultural area. A 12-year retrospective study.

Tesifon Parron, Antonio F. Hernández, Enrique Villanueva (1996)

Several reports have suggested that exposure to agricultural pesticides (mainly chronic exposure to organophosphates) produces depression, and depression is a major risk factor for suicide. A retrospective epidemiological study of 251 suicide cases was undertaken to explore the possible relationship between the high suicide rates in an intensive agricultural area, and a specific group of population at risk, namely farmers with chronic exposure to pesticides, who are at risk to develop mood disorders (mainly depression). Our data show that the suicide rate in that area is significantly higher than the suicide rates from other geographic areas with very similar socioeconomic and demographic features. In addition, the mortality from suicide in this population (farmers) does differ significantly from that of the rest of the population.