Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials.

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Abstract

In 2015, five randomised trials showed efficacy of endovascular thrombectomy over standard medical care in patients with acute ischaemic stroke caused by occlusion of arteries of the proximal anterior circulation. In this meta-analysis we, the trial investigators, aimed to pool individual patient data from these trials to address remaining questions about whether the therapy is efficacious across the diverse populations included.

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Journal

Journal ID (iso-abbrev): Lancet

Title: Lancet (London, England)

ISSN (Electronic): 1474-547X

ISSN (Print): 0140-6736

Publication date (Electronic): Apr 23 2016

Volume: 387

Issue: 10029

Affiliations

[1 ] Departments of Clinical Neuroscience and Radiology, Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Calgary, AB, Canada.

[2 ] Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, Netherlands.

[3 ] Erasmus MC University Medical Center, Rotterdam, Netherlands.

[4 ] Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC, Australia.

[5 ] Hospital Germans Trias y Pujol, Barcelona, Spain.

[6 ] Academic Medical Center, Amsterdam, Netherlands.

[7 ] Hospital de Bellvitge, Barcelona, Spain.

[8 ] Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia.

[9 ] Hospital Guy de Chaulliac, Montpellier, France.

[10 ] UCLA Medical Center, Los Angeles, CA, USA.

[11 ] Department of Neurology, University Hospital Essen, Essen, Germany.

[12 ] State University of New York, Buffalo, Buffalo, NY, USA.

[13 ] University of Toronto, Toronto, ON, Canada.

[14 ] University of Edmonton, Edmonton, AB, Canada.

[15 ] Hospital Germans Trials y Pujol, Barcelona, Spain.

[16 ] Department of Medicine and Neurology, Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC, Australia.

[17 ] CHUM Notre-Dame Hospital, Montreal, QC, Canada.

[18 ] Beaumont Hospital, Dublin, Ireland.

[19 ] Hospital Clinic, Barcelona, Spain.

[20 ] Hospital Vall d'Hebron, Barcelona, Spain.

[21 ] Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA.

[22 ] Altair Biostatistics, St Louis Park, MN, USA.

[23 ] David Geffen School of Medicine, University of Los Angeles, Los Angeles, CA, USA.

[24 ] University of Pittsburgh Medical Center Stroke Institute, Presbyterian University Hospital, Pittsburgh, PA, USA. Electronic address: jovintg@upmc.edu.

Article

Publisher Item ID: S0140-6736(16)00163-X

DOI: 10.1016/S0140-6736(16)00163-X

PubMed ID: 26898852

SO-VID: 4ea01a88-f50a-4618-8d45-03c2a5932d8e

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