The role of ipRGCs in ocular growth and myopia development

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Abstract

The increasing global prevalence of myopia calls for elaboration of the pathogenesis of this disease. Here, we show that selective ablation and activation of intrinsically photosensitive retinal ganglion cells (ipRGCs) in developing mice induced myopic and hyperopic refractive shifts by modulating the corneal radius of curvature (CRC) and axial length (AL) in an opposite way. Melanopsin- and rod/cone-driven signals of ipRGCs were found to influence refractive development by affecting the AL and CRC, respectively. The role of ipRGCs in myopia progression is evidenced by attenuated form-deprivation myopia magnitudes in ipRGC-ablated and melanopsin-deficient animals and by enhanced melanopsin expression/photoresponses in form-deprived eyes. Cell subtype–specific ablation showed that M1 subtype cells, and probably M2/M3 subtype cells, are involved in ocular development. Thus, ipRGCs contribute substantially to mouse eye growth and myopia development, which may inspire novel strategies for myopia intervention.

Abstract

A subset of retinal ganglion cells responsible for non–image-forming vision is found to modulate visually guided eye growth.

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Author and article information

Contributors

Ai-Lin Liu:

ORCID: https://orcid.org/0000-0002-0774-0701

Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SoftwareRole: SupervisionRole: ValidationRole: VisualizationRole: Writing - original draftRole: Writing - review & editing

Yun-Feng Liu: Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole: ValidationRole: VisualizationRole: Writing - original draftRole: Writing - review & editing

Ge Wang: Role: InvestigationRole: Project administrationRole: Writing - review & editing

Yu-Qi Shao: Role: InvestigationRole: Visualization

Chen-Xi Yu:

ORCID: https://orcid.org/0000-0003-3647-6310

Role: InvestigationRole: ResourcesRole: ValidationRole: Writing - review & editing

Zhe Yang: Role: InvestigationRole: MethodologyRole: Validation

Zi-Rui Zhou: Role: InvestigationRole: ResourcesRole: Validation

Xu Han:

ORCID: https://orcid.org/0000-0003-0537-0249

Role: InvestigationRole: Writing - review & editing

Xue Gong: Role: Investigation

Kang-Wei Qian: Role: InvestigationRole: Writing - review & editing

Li-Qin Wang: Role: Investigation

Yuan-Yuan Ma: Role: Methodology

Yong-Mei Zhong:

ORCID: https://orcid.org/0000-0002-3382-2655

Role: Formal analysisRole: Funding acquisitionRole: MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole: Writing - review & editing

Shi-Jun Weng:

ORCID: https://orcid.org/0000-0001-6550-892X

Role: ConceptualizationRole: Funding acquisitionRole: MethodologyRole: Project administrationRole: SupervisionRole: ValidationRole: VisualizationRole: Writing - original draftRole: Writing - review & editing

Xiong-Li Yang:

ORCID: https://orcid.org/0000-0003-2128-9950

Role: ConceptualizationRole: Funding acquisitionRole: SupervisionRole: ValidationRole: Writing - original draftRole: Writing - review & editing

Journal

Journal ID (nlm-ta): Sci Adv

Journal ID (iso-abbrev): Sci Adv

Journal ID (publisher-id): sciadv

Journal ID (hwp): advances

Title: Science Advances

Publisher: American Association for the Advancement of Science

ISSN (Electronic): 2375-2548

Publication date Collection: June 2022

Publication date (Electronic, pub): 08 June 2022

Volume: 8

Issue: 23

Electronic Location Identifier: eabm9027

Affiliations

[1]State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, 138 Yixueyuan Road, Shanghai, China.

Author notes

[* ]Corresponding author. Email: xlyang@ 123456fudan.edu.cn (X.-L.Y.); sjweng@ 123456fudan.edu.cn (S.-J.W.); ymzhong@ 123456fudan.edu.cn (Y.-M.Z.)

Author information

Ai-Lin Liu https://orcid.org/0000-0002-0774-0701

Chen-Xi Yu https://orcid.org/0000-0003-3647-6310

Xu Han https://orcid.org/0000-0003-0537-0249

Yong-Mei Zhong https://orcid.org/0000-0002-3382-2655

Shi-Jun Weng https://orcid.org/0000-0001-6550-892X

Xiong-Li Yang https://orcid.org/0000-0003-2128-9950

Article

Publisher ID: abm9027

DOI: 10.1126/sciadv.abm9027

PMC ID: 9176740

PubMed ID: 35675393

SO-VID: 4e36ec05-f9c0-4969-8a49-4bf7b8e3d82a

Copyright © Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.