Bioactive Glass Applications in Dentistry

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Abstract

At present, researchers in the field of biomaterials are focusing on the oral hard and soft tissue engineering with bioactive ingredients by activating body immune cells or different proteins of the body. By doing this natural ground substance, tissue component and long-lasting tissues grow. One of the current biomaterials is known as bioactive glass (BAG). The bioactive properties make BAG applicable to several clinical applications involving the regeneration of hard tissues in medicine and dentistry. In dentistry, its uses include dental restorative materials, mineralizing agents, as a coating material for dental implants, pulp capping, root canal treatment, and air-abrasion, and in medicine it has its applications from orthopedics to soft-tissue restoration. This review aims to provide an overview of promising and current uses of bioactive glasses in dentistry.

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Most cited references 192

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Mesoporous materials for drug delivery.

María Vallet-Regí, Francisco Balas, Daniel Arcos (2007)

Research on mesoporous materials for biomedical purposes has experienced an outstanding increase during recent years. Since 2001, when MCM-41 was first proposed as drug-delivery system, silica-based materials, such as SBA-15 or MCM-48, and some metal-organic frameworks have been discussed as drug carriers and controlled-release systems. Mesoporous materials are intended for both systemic-delivery systems and implantable local-delivery devices. The latter application provides very promising possibilities in the field of bone-tissue repair because of the excellent behavior of these materials as bioceramics. This Minireview deals with the advances in this field by the control of the textural parameters, surface functionalization, and the synthesis of sophisticated stimuli-response systems.

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THE ATOMIC ARRANGEMENT IN GLASS

W. Zachariasen (1932)

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The story of Bioglass.

Larry L Hench (2006)

Historically the function of biomaterials has been to replace diseased or damaged tissues. First generation biomaterials were selected to be as bio-inert as possible and thereby minimize formation of scar tissue at the interface with host tissues. Bioactive glasses were discovered in 1969 and provided for the first time an alternative; second generation, interfacial bonding of an implant with host tissues. Tissue regeneration and repair using the gene activation properties of Bioglass provide a third generation of biomaterials. This article reviews the 40 year history of the development of bioactive glasses, with emphasis on the first composition, 45S5 Bioglass, that has been in clinical use since 1985. The steps of discovery, characterization, in vivo and in vitro evaluation, clinical studies and product development are summarized along with the technology transfer processes.

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Journal

Journal ID (nlm-ta): Int J Mol Sci

Journal ID (iso-abbrev): Int J Mol Sci

Journal ID (publisher-id): ijms

Title: International Journal of Molecular Sciences

Publisher: MDPI

ISSN (Electronic): 1422-0067

Publication date (Electronic): 27 November 2019

Publication date Collection: December 2019

Volume: 20

Issue: 23

Electronic Location Identifier: 5960

Affiliations

[1 ]Faculty of Dentistry, University of Oslo, 0455 Oslo, Norway; herlings7b@ 123456msn.com

[2 ]Informetrics Research Group, Ton Duc Thang University, Ho Chi Minh City 7000, Vietnam

[3 ]Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 7000, Vietnam

[4 ]Prosthodontic and Dental Implantology Department, College of Dentistry, King Faisal University, Al-Hofuf, Al-Ahsa 31982, Saudi Arabia; drzohaibkhurshid@ 123456gmail.com

[5 ]Department of Restorative Dentistry, College of Dentistry, Taibah University, Al Madinah, Al Munawwarah 41311, Saudi Arabia; mzafar@ 123456taibahu.edu.sa

[6 ]Islamic International Dental College, Riphah International University Islamabad 44000, Pakistan

Author notes

[* ]Correspondence: dinesh.rokaya@ 123456tdtu.edu.vn

Author information

Dinesh Rokaya https://orcid.org/0000-0002-3854-667X

Zohaib Khurshid https://orcid.org/0000-0001-7998-7335

Muhammad Sohail Zafar https://orcid.org/0000-0002-5157-7067

Article

Publisher ID: ijms-20-05960

DOI: 10.3390/ijms20235960

PMC ID: 6928922

PubMed ID: 31783484

SO-VID: 4c5380f3-5098-4fd2-80ab-5ce8d8811d70

License:

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

Bioactive Glass Applications in Dentistry

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Abstract

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Higher order chromatin architecture

Most cited references 192

Mesoporous materials for drug delivery.

THE ATOMIC ARRANGEMENT IN GLASS

The story of Bioglass.

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