Dermoscopy, with and without visual inspection, for diagnosing melanoma in adults

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. Although history-taking and visual inspection of a suspicious lesion by a clinician are usually the first in a series of 'tests' to diagnose skin cancer, dermoscopy has become an important tool to assist diagnosis by specialist clinicians and is increasingly used in primary care settings. Dermoscopy is a magnification technique using visible light that allows more detailed examination of the skin compared to examination by the naked eye alone. Establishing the additive value of dermoscopy over and above visual inspection alone across a range of observers and settings is critical to understanding its contribution for the diagnosis of melanoma and to future understanding of the potential role of the growing number of other high-resolution image analysis techniques.

Related collections

Most cited references 342

Record: found
Abstract: found
Article: not found

Final version of 2009 AJCC melanoma staging and classification.

Charles M. Balch, Jeffrey Gershenwald, Seng-jaw Soong … (2010)

To revise the staging system for cutaneous melanoma on the basis of data from an expanded American Joint Committee on Cancer (AJCC) Melanoma Staging Database. The melanoma staging recommendations were made on the basis of a multivariate analysis of 30,946 patients with stages I, II, and III melanoma and 7,972 patients with stage IV melanoma to revise and clarify TNM classifications and stage grouping criteria. Findings and new definitions include the following: (1) in patients with localized melanoma, tumor thickness, mitotic rate (histologically defined as mitoses/mm(2)), and ulceration were the most dominant prognostic factors. (2) Mitotic rate replaces level of invasion as a primary criterion for defining T1b melanomas. (3) Among the 3,307 patients with regional metastases, components that defined the N category were the number of metastatic nodes, tumor burden, and ulceration of the primary melanoma. (4) For staging purposes, all patients with microscopic nodal metastases, regardless of extent of tumor burden, are classified as stage III. Micrometastases detected by immunohistochemistry are specifically included. (5) On the basis of a multivariate analysis of patients with distant metastases, the two dominant components in defining the M category continue to be the site of distant metastases (nonvisceral v lung v all other visceral metastatic sites) and an elevated serum lactate dehydrogenase level. Using an evidence-based approach, revisions to the AJCC melanoma staging system have been made that reflect our improved understanding of this disease. These revisions will be formally incorporated into the seventh edition (2009) of the AJCC Cancer Staging Manual and implemented by early 2010.

0 comments Cited 1185 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Dermoscopy of pigmented skin lesions: results of a consensus meeting via the Internet.

Giuseppe Argenziano, H. Soyer, Sergio Chimenti … (2003)

There is a need for better standardization of the dermoscopic terminology in assessing pigmented skin lesions. The virtual Consensus Net Meeting on Dermoscopy was organized to investigate reproducibility and validity of the various features and diagnostic algorithms. Dermoscopic images of 108 lesions were evaluated via the Internet by 40 experienced dermoscopists using a 2-step diagnostic procedure. The first-step algorithm distinguished melanocytic versus nonmelanocytic lesions. The second step in the diagnostic procedure used 4 algorithms (pattern analysis, ABCD rule, Menzies method, and 7-point checklist) to distinguish melanoma versus benign melanocytic lesions. kappa Values, log odds ratios, sensitivity, specificity, and positive likelihood ratios were estimated for all diagnostic algorithms and dermoscopic features. Interobserver agreement was fair to good for all diagnostic methods, but it was poor for the majority of dermoscopic criteria. Intraobserver agreement was good to excellent for all algorithms and features considered. Pattern analysis allowed the best diagnostic performance (positive likelihood ratio: 5.1), whereas alternative algorithms revealed comparable sensitivity but less specificity. Interobserver agreement on management decisions made by dermoscopy was fairly good (mean kappa value: 0.53). The virtual Consensus Net Meeting on Dermoscopy represents a valid tool for better standardization of the dermoscopic terminology and, moreover, opens up a new territory for diagnosing and managing pigmented skin lesions.

0 comments Cited 195 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

International trends in the incidence of malignant melanoma 1953-2008--are recent generations at higher or lower risk?

Friederike Erdmann, Joannie Lortet-Tieulent, Joachim Schüz … (2013)

The incidence of cutaneous malignant melanoma has steadily increased over the past 50 years in predominately fair-skinned populations. This increase is reported to have leveled off recently in several Northern and Western European countries, Australia, New Zealand and in North America. We studied the global patterns and time trends in incidence of melanoma by country and sex, with a focus on and age- and cohort-specific variations. We analyzed the incidence data from 39 population-based cancer registries, examining all-ages and age-truncated standardized incidence rates of melanoma, estimating the annual percentage change and incidence rate ratios from age-period-cohort models. Incidence rates of melanoma continue to rise in most European countries (primarily Southern and Eastern Europe), whereas in Australia, New Zealand, the U.S., Canada, Israel and Norway, rates have become rather stable in recent years. Indications of a stabilization or decreasing trend were observed mainly in the youngest age group (25-44 years). Rates have been rising steadily in generations born up to the end of the 1940s, followed by a stabilization or decline in rates for more recently born cohorts in Australia, New Zealand, the U.S., Canada and Norway. In addition to the birth cohort effect, there was a suggestion of a period-related influence on melanoma trends in certain populations. Although our findings provide support that primary and secondary prevention can halt and reverse the observed increasing burden of melanoma, they also indicate that those prevention measures require further endorsement in many countries. Copyright © 2012 UICC.

0 comments Cited 188 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Title: Cochrane Database of Systematic Reviews

Publisher: Wiley

ISSN (Electronic): 14651858

Publication date (Electronic): December 04 2018

Affiliations

[1 ]University of Birmingham; Institute of Applied Health Research; Birmingham UK B15 2TT

[2 ]University Hospitals Birmingham NHS Foundation Trust and University of Birmingham; NIHR Birmingham Biomedical Research Centre; Birmingham UK

[3 ]Churchill Hospital; Department of Dermatology; Old Road Headington Oxford UK OX3 7LE

[4 ]St George's Hospital; Department of Plastic Surgery; London UK

[5 ]Oxford University Hospitals NHS Foundation Trust; Department of Plastic and Reconstructive Surgery; Oxford UK

[6 ]NHS Lothian/University of Edinburgh; Department of Plastic Surgery; 25/6 India Street Edinburgh UK EH3 6HE

[7 ]University Hospital of Wales; Welsh Institute of Dermatology; Heath Park Cardiff UK CF14 4XW

[8 ]Norfolk and Norwich University Hospital NHS Trust; Department of Plastic and Reconstructive Surgery; Colney Lane Norwich UK NR4 7UY

[9 ]School of Medicine; Division of Epidemiology and Public Health; University of Nottingham Nottingham UK NG7 2UH

[10 ]The University of Nottingham; c/o Cochrane Skin Group; Nottingham UK

[11 ]University of Cambridge; Public Health & Primary Care; Strangeways Research Laboratory, Worts Causeway Cambridge UK CB1 8RN

[12 ]University of Nottingham; Centre of Evidence Based Dermatology; Queen's Medical Centre Derby Road Nottingham UK NG7 2UH

Article

DOI: 10.1002/14651858.CD011902.pub2

PMC ID: 6517096

PubMed ID: 30521682

SO-VID: 4c43dd64-2c30-4634-b3e1-ead7da4e6e7a

History

Data availability:

Comments

Comment on this article

scite_

Cited by 57

See all cited by

- Version 1
- Version 1

Dermoscopy, with and without visual inspection, for diagnosing melanoma in adults

Read this article at

Abstract

Related collections

Vision Science collection

Most cited references 342

Final version of 2009 AJCC melanoma staging and classification.

Dermoscopy of pigmented skin lesions: results of a consensus meeting via the Internet.

International trends in the incidence of malignant melanoma 1953-2008--are recent generations at higher or lower risk?

Author and article information

Journal

Affiliations

Article

History

Comments

Comment on this article

Similar content 4,352

Cited by 57