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      Towards eco-friendly pharmaceuticals: Regulatory and policy approaches for sustainable medicines use

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          Abstract

          Objectives

          The current study aimed to investigate how regulatory frameworks and policies are used to support the use of sustainable medicines within the pharmaceutical sector.

          Methods

          The Scopus database was searched to retrieve papers. Advanced search tool of the Scopus online database was used focused on the papers that have the search query included in their titles. Data analysis incorporated bibliometric indicators like publication counts and trends, visualized through VOSviewer software version 1.6.20.

          Key findings

          A total of 43 publications on Sustainable Medicines Use were found between 2000 and 2024. Leading countries in publication output on sustainable medicines use were United Kingdom, United States, India, Italy, Portugal, and Switzerland, indicating their collaborative relationships and publication volumes. A total of 92 institutions have been involved in research on Sustainable Medicines Use. Key institutions such as the Faculty of Engineering and the Laboratory for Process and Environmental Engineering, Lowell Center for Sustainable Production, Greiner Environmental Inc., and the University of Florence are prominently featured, indicating their significant contributions to research in this area. Key journals such as the “Journal of Cleaner Production,” “Business Strategy and the Environment,” “Chemical Engineering Transactions,” “Benchmarking,” and “Lecture Notes in Mechanical Engineering” are prominently featured. The retrieved articles have been cited an average count of 22.26. The overlay visualization created using VOSviewer suggest a shift towards exploring new drug categories, innovative approaches, and the commercial aspects of sustainability. Future research directions are likely to delve deeper into innovative methods and sustainable chemical practices (green chemistry), reflecting an emphasis on developing greener processes and products.

          Conclusion

          This study offers a thorough analysis of the legislative and governmental strategies promoting the use of sustainable medicine. It offers important insights for promoting sustainability in the pharmaceutical industry by pointing out gaps, defining useful frameworks, and suggesting doable solutions. Achieving sustainable pharmaceutical practices that support worldwide environmental and public health objectives requires sustained research, policy development, and international cooperation. The area needs to keep developing and implementing sustainable methods like green chemistry to decrease environmental harm and improve sustainability. Furthermore, collaborations among academia, industry, and international organizations are essential to progress and interchange effective strategies.

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          Most cited references42

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          Comparison of PubMed, Scopus, Web of Science, and Google Scholar: strengths and weaknesses.

          The evolution of the electronic age has led to the development of numerous medical databases on the World Wide Web, offering search facilities on a particular subject and the ability to perform citation analysis. We compared the content coverage and practical utility of PubMed, Scopus, Web of Science, and Google Scholar. The official Web pages of the databases were used to extract information on the range of journals covered, search facilities and restrictions, and update frequency. We used the example of a keyword search to evaluate the usefulness of these databases in biomedical information retrieval and a specific published article to evaluate their utility in performing citation analysis. All databases were practical in use and offered numerous search facilities. PubMed and Google Scholar are accessed for free. The keyword search with PubMed offers optimal update frequency and includes online early articles; other databases can rate articles by number of citations, as an index of importance. For citation analysis, Scopus offers about 20% more coverage than Web of Science, whereas Google Scholar offers results of inconsistent accuracy. PubMed remains an optimal tool in biomedical electronic research. Scopus covers a wider journal range, of help both in keyword searching and citation analysis, but it is currently limited to recent articles (published after 1995) compared with Web of Science. Google Scholar, as for the Web in general, can help in the retrieval of even the most obscure information but its use is marred by inadequate, less often updated, citation information.
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            Pharmaceuticals and Personal Care Products in the Environment: What Are the Big Questions?

            Background: Over the past 10–15 years, a substantial amount of work has been done by the scientific, regulatory, and business communities to elucidate the effects and risks of pharmaceuticals and personal care products (PPCPs) in the environment. Objective: This review was undertaken to identify key outstanding issues regarding the effects of PPCPs on human and ecological health in order to ensure that future resources will be focused on the most important areas. Data sources: To better understand and manage the risks of PPCPs in the environment, we used the “key question” approach to identify the principle issues that need to be addressed. Initially, questions were solicited from academic, government, and business communities around the world. A list of 101 questions was then discussed at an international expert workshop, and a top-20 list was developed. Following the workshop, workshop attendees ranked the 20 questions by importance. Data synthesis: The top 20 priority questions fell into seven categories: a) prioritization of substances for assessment, b) pathways of exposure, c) bioavailability and uptake, d) effects characterization, e) risk and relative risk, f ) antibiotic resistance, and g) risk management. Conclusions: A large body of information is now available on PPCPs in the environment. This exercise prioritized the most critical questions to aid in development of future research programs on the topic.
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              Scopus as a curated, high-quality bibliometric data source for academic research in quantitative science studies

              Scopus is among the largest curated abstract and citation databases, with a wide global and regional coverage of scientific journals, conference proceedings, and books, while ensuring only the highest quality data are indexed through rigorous content selection and re-evaluation by an independent Content Selection and Advisory Board. Additionally, extensive quality assurance processes continuously monitor and improve all data elements in Scopus. Besides enriched metadata records of scientific articles, Scopus offers comprehensive author and institution profiles, obtained from advanced profiling algorithms and manual curation, ensuring high precision and recall. The trustworthiness of Scopus has led to its use as bibliometric data source for large-scale analyses in research assessments, research landscape studies, science policy evaluations, and university rankings. Scopus data have been offered for free for selected studies by the academic research community, such as through application programming interfaces, which have led to many publications employing Scopus data to investigate topics such as researcher mobility, network visualizations, and spatial bibliometrics. In June 2019, the International Center for the Study of Research was launched, with an advisory board consisting of bibliometricians, aiming to work with the scientometric research community and offering a virtual laboratory where researchers will be able to utilize Scopus data.
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                Author and article information

                Contributors
                Journal
                Explor Res Clin Soc Pharm
                Explor Res Clin Soc Pharm
                Exploratory Research in Clinical and Social Pharmacy
                Elsevier
                2667-2766
                06 February 2025
                March 2025
                06 February 2025
                : 17
                : 100576
                Affiliations
                [a ]Health and Safety Department, Dubai Municipality, Dubai, United Arab Emirates
                [b ]Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia (USM), Pulau Pinang 11500, Malaysia
                [c ]Pharmacy Department, Emirates Health Services, Dubai, United Arab Emirates
                [d ]Centre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman 346, United Arab Emirates
                [e ]Department of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman 346, United Arab Emirates
                [f ]Clinical Pharmacy Program, College of Pharmacy, Al Ain University, Al Ain, United Arab Emirates
                [g ]AAU Health and Biomedical Research Center, Al Ain University, Abu Dhabi, United Arab Emirates
                [h ]Department of Clinical Pharmacy & Pharmacotherapeutics, Dubai Pharmacy College for Girls, AlMuhaisanah 1, Al mizhar Dubai, United Arab Emirates
                [i ]Department of Clinical and Community Pharmacy, College of Medicine and Health Sciences, An-Najah, National University, Nablus 44839, Palestine
                [j ]Clinical Research Centre, An-Najah National University Hospital, Nablus 44839, Palestine
                Author notes
                [* ]Corresponding author at: Health and Safety Department, Dubai Municipality, Dubai, United Arab Emirates. Dr_ammar_91_@ 123456hotmail.com
                [∗∗ ]Corresponding author at: Centre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman 346, United Arab Emirates. moyad76@ 123456hotmail.com
                Article
                S2667-2766(25)00017-4 100576
                10.1016/j.rcsop.2025.100576
                11871503
                40026320
                4c2c1876-8239-4163-89c0-020d94bf735e
                © 2025 The Authors

                This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

                History
                : 9 October 2024
                : 3 February 2025
                : 4 February 2025
                Categories
                Article

                sustainable medicines,sustainable pharmaceuticals,sustainability,environmental impact

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