Contributors
Mathula Thangarajh: Role: ConceptualizationRole: Data curationRole: Funding acquisitionRole: InvestigationRole:
MethodologyRole: Project administrationRole: ResourcesRole: Writing – original draftRole:
Writing – review & editing
Aiping Zhang: Role: InvestigationRole: Writing – original draftRole: Writing – review & editing
Kirandeep Gill: Role: InvestigationRole: MethodologyRole: ValidationRole: Writing – original draftRole:
Writing – review & editing
Habtom W. Ressom: Role: Data curationRole: InvestigationRole: SoftwareRole: SupervisionRole: Writing
– original draftRole: Writing – review & editing
Zhenzhi Li: Role: InvestigationRole: MethodologyRole: SoftwareRole: Writing – original draftRole:
Writing – review & editing
Rency S. Varghese: Role: Data curationRole: Formal analysisRole: SoftwareRole: Writing – review & editing
Eric P. Hoffman: Role: InvestigationRole: Writing – original draftRole: Writing – review & editing
Kanneboyina Nagaraju: Role: InvestigationRole: MethodologyRole: ResourcesRole: SupervisionRole: Writing
– original draftRole: Writing – review & editing
Yetrib Hathout: Role: Funding acquisitionRole: InvestigationRole: MethodologyRole: ResourcesRole:
SupervisionRole: Writing – original draftRole: Writing – review & editing
Simina M. Boca:
ORCID: http://orcid.org/0000-0002-1400-3398
Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Project administrationRole: SoftwareRole: SupervisionRole: VisualizationRole: Writing
– original draftRole: Writing – review & editing
Matthew Cooke: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date Collection: 2019
Publication date
(Electronic):
16
July
2019
Volume: 14
Issue: 7
Electronic Location Identifier: e0219507
Affiliations
[1
]
Department of Neurology, George Washington University School of Medicine and Children’s
National Health Systems, Washington, D.C., United States of America
[2
]
Department of Genomics and Precision Medicine, George Washington University School
of Medicine and Children’s National Health Systems, Washington, D.C., United States
of America
[3
]
Department of Oncology, Georgetown University Medical Center, Washington, D.C., United
States of America
[4
]
School of Pharmacy & Pharmaceutical Sciences, Binghamton University, Binghamton, N.Y.,
United States of America
[5
]
Innovation Center for Biomedical Informatics, Georgetown University Medical Center,
Washington, D.C., United States of America
[6
]
Department of Biostatistics, Bioinformatics and Biomathematics, Georgetown University
Medical Center, Washington, D.C., United States of America
Swinburne University of Technology, AUSTRALIA
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PONE-D-19-00276
DOI: 10.1371/journal.pone.0219507
PMC ID: 6634414
PubMed ID: 31310630
SO-VID: 4c26794f-fec3-41fc-8f2b-dc51476fa82c
Copyright © © 2019 Thangarajh et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 4
January
2019
Date
accepted
: 25
June
2019
Page count
Figures: 7,
Tables: 1,
Pages: 17
Funding
Funded by: funder-id http://dx.doi.org/10.13039/100000054, National Cancer Institute;
Award ID: P30CA051008
Funded by: funder-id http://dx.doi.org/10.13039/100005202, Muscular Dystrophy Association;
Award ID: MDA353094
Award Recipient
:
Yetrib Hathout
Funded by: American Academy of Neurology/American Brain Foundation
Award ID: Clinical Research Training Fellowship
Award Recipient
:
Mathula Thangarajh
MT acknowledges the support of the American Academy of Neurology/American Brain Foundation
Clinical Research Training Fellowship, (2015-2017). YH acknowledges the support of
the Muscular Dystrophy Association (MDA353094). This research was also supported by
the National Cancer Institute, (P30CA051008). The funders had no role in study design,
data collection and analysis, decision to publish, or preparation of the manuscript.
Categories
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Metabolism
Subject:
Metabolites
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Compounds
Subject:
Organic Compounds
Subject:
Creatine
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Organic Chemistry
Subject:
Organic Compounds
Subject:
Creatine
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Biomarkers
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Urine
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Urine
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Urine
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Urine
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Mouse Models
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Biomarkers
Subject:
Creatinine
Subject:
Medicine and Health Sciences
Subject:
Pharmacology
Subject:
Pharmacokinetics
Subject:
Drug Metabolism
Subject:
Medicine and Health Sciences
Subject:
Neurology
Subject:
Muscular Dystrophies
Subject:
Duchenne Muscular Dystrophy
Subject:
Medicine and Health Sciences
Subject:
Clinical Genetics
Subject:
X-Linked Traits
Subject:
Duchenne Muscular Dystrophy
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Heredity
Subject:
Genetic Linkage
Subject:
Sex Linkage
Subject:
X-Linked Traits
Subject:
Duchenne Muscular Dystrophy
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