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      The Magic Velvet Bean of Mucuna pruriens

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          Abstract

          Mucuna pruriens (Fabaceae) is an established herbal drug used for the management of male infertility, nervous disorders, and also as an aphrodisiac. It has been shown that its seeds are potentially of substantial medicinal importance. The ancient Indian medical system, Ayurveda, traditionally used M. pruriens, even to treat such things as Parkinson's disease. M. pruriens has been shown to have anti-parkinson and neuroprotective effects, which may be related to its anti-oxidant activity. In addition, anti-oxidant activity of M. pruriens has been also demonstrated in vitro by its ability to scavenge DPPH radicals and reactive oxygen species. In this review the medicinal properties of M. pruriens are summarized, taking in consideration the studies that have used the seeds extracts and the leaves extracts.

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          Antioxidant activity, lipid peroxidation and skin diseases. What's new.

          Due to its interface function between the body and the environment, the skin is chronically exposed to both endogenous and environmental pro-oxidant agents, leading to the harmful generation of reactive oxygen species (ROS). There is compelling evidence that oxidative stress is involved in the damage of cellular constituents, such as DNA, cell membrane lipids or proteins. To protect the skin against the over-load of oxidant species, it contains a well-organised system of both chemical and enzymatic antioxidant which are able to work in a synergistic manner. Skin antioxidant network protects cells against oxidative injury and prevent the production of oxidation products, such as 4-hydroxy-2-nonenal or malonaldehyde, which are able to induce protein damage, apoptosis or release of pro-inflammatory mediators, such as cytokines. When oxidative stress overwhelms the skin antioxidant capacity the subsequent modification of cellular redox apparatus leads to an alteration of cell homeostasis and a generation of degenerative processes. Topical application or oral administration of antioxidants has been recently suggested as preventive therapy for skin photoaging and UV-induced cancer. The recognition that ROS can act as second messengers in the induction of several biological responses, such as the activation of NF-kB or AP-1, the generation of cytokines, the modulation of signalling pathways, etc., has led many researchers to focus on the possible effects of antioxidants in many pathological processes. The recent demonstration that the peroxisome proliferators-activated receptors, whose natural ligands are polyunsaturated fatty acids and theirs oxidation products, have a central role in the induction of some skin diseases, such as psoriasis or acne, has indicated new links between free radicals and skin inflammation. Based on these findings, the review summarises the possible correlations between antioxidant imbalance, lipid oxidative breakage and skin diseases, from both a pathological and therapeutic points of view.
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            Phenolic Content and Antioxidant Activity of Pearled Wheat and Roller-Milled Fractions

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              The ecological basis for the application of traditional agricultural technology in the management of tropical agro-ecosystems

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                Author and article information

                Journal
                J Tradit Complement Med
                J Tradit Complement Med
                JTCM
                Journal of Traditional and Complementary Medicine
                Medknow Publications & Media Pvt Ltd (India )
                2225-4110
                Oct-Dec 2012
                : 2
                : 4
                : 331-339
                Affiliations
                [1 ]Department of Chemistry, University of Siena, Italy.
                [2 ]Department of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, Italy.
                [3 ]Department of Life Science and Biotechnologies, University of Ferrara, Ferrara, Italy
                [4 ]Department of Food and Nutrition, Kyung Hee University, Seoul, South Korea
                Author notes
                [* ] Correspondence to: Prof. Giuseppe Valacchi , Department of Life Science and Biotechnologies, University of Ferrara, Via Borsari 46, Ferrara, 44100, Tel: +39 0532 455482, Fax: +30 0532 455450, Giuseppe.valacchi@ 123456unife.it
                Article
                JTCM-2-331
                10.1016/S2225-4110(16)30119-5
                3942911
                24716148
                4bb8130b-72cc-4b7a-ade3-fa74a9d63fc3
                Copyright: © Journal of Traditional and Complementary Medicine

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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                Categories
                Review Article

                mucuna pruriens,phytochemicals,antioxidant,parkinson's disease,skin,diabetes

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