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Identification of mismatch repair gene mutations in young patients with colorectal cancer and in patients with multiple tumours associated with hereditary non-polyposis colorectal cancer.
R C Niessen
1 ,
M J W Berends ,
Y Wu ,
R H Sijmons ,
H Hollema ,
M J L Ligtenberg ,
H E K de Walle ,
E G E de Vries ,
A Karrenbeld ,
C H C M Buys ,
A G J van der Zee ,
R M W Hofstra ,
J H Kleibeuker
Dec 2006
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Abstract
Patients with early-onset colorectal cancer (CRC) or those with multiple tumours associated with hereditary non-polyposis colorectal cancer (HNPCC) raise suspicion of the presence of germline DNA mismatch repair (MMR) gene mutations.
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