American Society for Bone and Mineral Research‐Orthopaedic Research Society Joint Task Force Report on Cell‐Based Therapies

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Abstract

Cell-based therapies, defined here as the delivery of cells in vivo to treat disease, have recently gained increasing public attention as a potentially promising approach to restore structure and function to musculoskeletal tissues. Although cell-based therapy has the potential to improve the treatment of disorders of the musculoskeletal system, there is also the possibility of misuse and misrepresentation of the efficacy of such treatments. The medical literature contains anecdotal reports and research studies, along with web-based marketing and patient testimonials supporting cell-based therapy. Both the American Society for Bone and Mineral Research (ASBMR) and the Orthopaedic Research Society (ORS) are committed to ensuring that the potential of cell-based therapies is realized through rigorous, reproducible, and clinically meaningful scientific discovery. The two organizations convened a multidisciplinary and international Task Force composed of physicians, surgeons, and scientists who are recognized experts in the development and use of cell-based therapies. The Task Force was charged with defining the state-of-the art in cell-based therapies and identifying the gaps in knowledge and methodologies that should guide the research agenda. The efforts of this Task Force are designed to provide researchers and clinicians with a better understanding of the current state of the science and research needed to advance the study and use of cell-based therapies for skeletal tissues. The design and implementation of rigorous, thorough protocols will be critical to leveraging these innovative treatments and optimizing clinical and functional patient outcomes. In addition to providing specific recommendations and ethical considerations for preclinical and clinical investigations, this report concludes with an outline to address knowledge gaps in how to determine the cell autonomous and nonautonomous effects of a donor population used for bone regeneration. © 2019 American Society for Bone and Mineral Research.

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Most cited references 83

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Author and article information

Journal

Title: Journal of Bone and Mineral Research

Abbreviated Title: J Bone Miner Res

Publisher: Wiley

ISSN (Print): 0884-0431

ISSN (Electronic): 1523-4681

Publication date Created: September 23 2019

Publication date Created: January 2020

Publication date (Electronic): September 23 2019

Publication date (Print): January 2020

Volume: 35

Issue: 1

Pages: 3-17

Affiliations

[1 ]Department of Orthopaedic SurgerySchool of Medicine, Washington University St. Louis MO USA

[2 ]The Chinese University of Hong Kong, Institute for Tissue Engineering and Regenerative Medicine Hong Kong SAR China

[3 ]Department of MedicineUniversity of California Davis CA USA

[4 ]Department of Biomedical EngineeringDepartment of Orthopaedics and Rehabilitation University of Rochester, Rochester NY USA

[5 ]Regenerative Medicine InstituteNational University of Ireland Galway Galway Ireland

[6 ]Department of PharmacologySchool of Medicine, Tulane University New Orleans LA USA

[7 ]INSERM UMR 1163Imagine Institute Paris France

[8 ]Department of EndocrinologyMayo Clinic Rochester MN USA

[9 ]Department of OrthopaedicsEmory Healthcare, Emory University Tucker GA USA

[10 ]Department of Orthopaedic SurgeryMcKay Orthopaedic Research Laboratory, University of Pennsylvania Philadelphia PA USA

[11 ]College of Veterinary MedicineCornell University Ithaca NY USA

[12 ]Phil and Penny Knight Campus for Accelerating Scientific ImpactUniversity of Oregon Eugene OR USA

[13 ]Mount Sinai HospitalUniversity of Toronto Toronto, ON Canada

[14 ]Orthopaedic Research and BiotechnologyKids Research Institute Westmead Australia

[15 ]Center for Biomedical Ethics and HumanitiesUniversity of Virginia Charlottesville VA USA

[16 ]Division of OrthodonticsCollege of Dental Medicine, Columbia University New York NY USA

[17 ]Institute for Medical Science in SportsOsaka Health Science University Osaka Japan

[18 ]Department of Orthopaedic Surgery, Sports Medicine Research Laboratory, Harvard Medical School/Boston Children's Hospital Boston MA USA

[19 ]Hospital for Special Surgery New York NY USA

[20 ]Department of Developmental BiologyHarvard School of Dental Medicine, Harvard University Boston MA USA

[21 ]Department of Orthopedic SurgeryColumbia University New York NY USA

[22 ]Center for Musculoskeletal ResearchUniversity of Rochester Rochester NY USA

[23 ]University of Alabama at Birmingham AL USA

Article

DOI: 10.1002/jbmr.3839

PubMed ID: 31545883

SO-VID: 4b9eed7b-7fee-4607-99ad-d4fdc76ff2f4

License:

http://onlinelibrary.wiley.com/termsAndConditions#vor

http://doi.wiley.com/10.1002/tdm_license_1.1

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