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      Deposition of boron doped DLC films on TiNb and characterization of their mechanical properties and blood compatibility

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          Abstract

          Diamond-like carbon (DLC) material is used in blood contacting devices as the surface coating material because of the antithrombogenicity behavior which helps to inhibit platelet adhesion and activation. In this study, DLC films were doped with boron during pulsed plasma chemical vapor deposition (CVD) to improve the blood compatibility. The ratio of boron to carbon (B/C) was varied from 0 to 0.4 in the film by adjusting the flow rate of trimethylboron and acetylene. Tribological tests indicated that boron doping with a low B/C ratio of 0.03 is beneficial for reducing friction (μ = 0.1), lowering hardness and slightly increasing wear rate compared to undoped DLC films. The B/C ratio in the film of 0.03 and 0.4 exhibited highly hydrophilic surface owing to their high wettability and high surface energy. An in vitro platelet adhesion experiment was conducted to compare the blood compatibility of TiNb substrates before and after coating with undoped and boron doped DLC. Films with highly hydrophilic surface enhanced the blood compatibility of TiNb, and the best results were obtained for DLC with the B/C ratio of 0.03. Boron doped DLC films are promising surface coatings for blood contacting devices.

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          Interpretation of protein adsorption: surface-induced conformational changes.

          Paul Roach, David T. Farrar, Carole C. Perry (2005)
          Protein adhesion plays a major role in determining the biocompatibility of materials. The first stage of implant integration is the adhesion of protein followed by cell attachment. Surface modification of implants (surface chemistry and topography) to induce and control protein and cell adhesion is currently of great interest. This communication presents data on protein adsorption (bovine serum albumin and fibrinogen) onto model hydrophobic (CH(3)) and hydrophilic (OH) surfaces, investigated using a quartz crystal microbalance (QCM) and grazing angle infrared spectroscopy. Our data suggest that albumin undergoes adsorption via a single step whereas fibrinogen adsorption is a more complex, multistage process. Albumin has a stronger affinity toward the CH(3) compared to OH terminated surface. In contrast, fibrinogen adheres more rapidly to both surfaces, having a slightly higher affinity toward the hydrophobic surface. Conformational assessment of the adsorbed proteins by grazing angle infrared spectroscopy (GA-FTIR) shows that after an initial 1 h incubation few further time-dependent changes are observed. Both proteins exhibited a less organized secondary structure upon adsorption onto a hydrophobic surface than onto a hydrophilic surface, with the effect observed greatest for albumin. This study demonstrates the ability of simple tailor-made monochemical surfaces to influence binding rates and conformation of bound proteins through protein-surface interactions. Current interest in biocompatible materials has focused on surface modifications to induce rapid healing, both of implants and for wound care products. This effect may also be of significance at the next stage of implant integration, as cell adhesion occurs through the surface protein layer.
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            Stress reduction and bond stability during thermal annealing of tetrahedral amorphous carbon

            N. Morrison, B. Kleinsorge, J. Robertson … (1999)
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              Hemocompatibility of titanium oxide films.

              N. Huang, P. Yang, Y.X. Leng … (2003)
              Hemocompatibility is a key property of biomaterials that come in contact with blood. Surface modification has shown great potential for improving the hemocompatibility of biomedical materials and devices. In this paper, we describe our work of improving hemocompatibility with Ti-O thin films prepared by plasma immersion ion implantation and deposition and by sputtering. The structure and surface chemical and physical properties of the films were characterized by X-ray diffraction, Auger electron spectroscopy, atomic force microscopy (AFM), contact angle measurement, and Hall effect measurement. The behavior of fibrinogen adsorption was investigated by 125I radioactive isotope labeling and AFM. Systematic evaluation of hemocompatibility, including in vitro clotting time, thrombin time, prethrombin time, platelet adhesion, and in vivo implantation into dog's ventral aorta or right auricle from 17 to 90 days, proved that Ti-O films have excellent hemocompatibility. It is suggested that the significantly lower interface tension between Ti-O films and blood and plasma proteins and the semiconducting nature of Ti-O films give them their improved hemocompatibility.
              Article 0 comments Cited 46 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Sci Technol Adv Mater
                Journal ID (iso-abbrev): Sci Technol Adv Mater
                Journal ID (archive): TSTA
                Journal ID (publisher-id): tsta20
                Title: Science and Technology of Advanced Materials
                Publisher: Taylor & Francis
                ISSN (Print): 1468-6996
                ISSN (Electronic): 1878-5514
                Publication date Collection: 2017
                Publication date (Electronic): 16 January 2017
                Volume: 18
                Issue: 1
                Pages: 76-87
                Affiliations
                [ a ]Department of Mechanical Sciences and Engineering, Tokyo Institute of Technology , Tokyo, Japan
                [ b ]Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University , Tokyo, Japan
                [ c ]Department of Mechanical Engineering, University of Malaya , Kuala Lumpur, Malaysia
                Author notes
                [* ]Corresponding author. Email: shahiraliza@ 123456gmail.com
                Article
                Publisher ID: 1262196
                DOI: 10.1080/14686996.2016.1262196
                PMC ID: 5256269
                SO-VID: 4ae0a7c5-4b95-4844-922f-7234d46ded28
                Copyright © © 2017 The Author(s). Published by National Institute for Materials Science in partnership with Taylor & Francis
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 15 June 2016
                Date revision received : 14 November 2016
                Date accepted : 15 November 2016
                Page count
                Figures: 10, Tables: 3, Equations: 0, References: 58, Pages: 12
                Funding
                Funded by: JSPS KAKENHI
                Award ID: 25289259
                Categories
                Subject: Article
                Subject: Engineering and Structural Materials

                Keywords: boron doped dlc film,thin film,tribology,wettability,surface energy,platelet adhesion and activation,10 engineering and structural materials,104 carbon and related materials,306 thin film / coatings
                Data availability:
                Keywords: boron doped dlc film, thin film, tribology, wettability, surface energy, platelet adhesion and activation, 10 engineering and structural materials, 104 carbon and related materials, 306 thin film / coatings

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