Methylation status of nc886 epiallele reflects periconceptional conditions and is associated with glucose metabolism through nc886 RNAs.

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Abstract

Non-coding RNA 886 (nc886) is coded from a maternally inherited metastable epiallele. We set out to investigate the determinants and dynamics of the methylation pattern at the nc886 epiallele and how this methylation status associates with nc886 RNA expression. Furthermore, we investigated the associations between the nc886 methylation status or the levels of nc886 RNAs and metabolic traits in the YFS and KORA cohorts. The association between nc886 epiallele methylation and RNA expression was also validated in induced pluripotent stem cell (iPSC) lines.

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Author and article information

Journal

Journal ID (iso-abbrev): Clin Epigenetics

Title: Clinical epigenetics

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1868-7083

ISSN (Print): 1868-7075

Publication date (Electronic): Jul 22 2021

Volume: 13

Issue: 1

Affiliations

[1 ] Department of Clinical Chemistry, Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Pirkanmaa Hospital District and Fimlab Laboratories, Tampere, Finland. Saara.Marttila@tuni.fi.

[2 ] Gerontology Research Center, Tampere University, Tampere, Finland. Saara.Marttila@tuni.fi.

[3 ] Heart Group, Finnish Cardiovascular Research Center, Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

[4 ] Department of Clinical Chemistry, Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Pirkanmaa Hospital District and Fimlab Laboratories, Tampere, Finland.

[5 ] Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Bavaria, Germany.

[6 ] Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, Germany.

[7 ] German Center for Diabetes Research (DZD), Munich, Neuherberg, Germany.

[8 ] Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research At Heinrich Heine University, Düsseldorf, Germany.

[9 ] Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.

[10 ] Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

[11 ] Department of Neurogenetics and Institute of Human Genetics, Technical University of Munich, Munich, Germany.

[12 ] German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.

[13 ] Department of Clinical Physiology, Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, Tampere, Finland.

[14 ] Tampere Centre for Skills Training and Simulation, Tampere University, Tampere, Finland.

[15 ] Division of Medicine, Department of Medicine, Turku University Hospital, University of Turku, Turku, Finland.

[16 ] Heart Hospital, Tampere University Hospital, Tampere University, Tampere, Finland.

[17 ] Centre for Population Health Research, University of Turku, Turku University Hospital, Turku, Finland.

[18 ] Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.

[19 ] Department of Clinical Physiology and Nuclear Medicine, University of Turku, Turku University Hospital, Turku, Finland.

[20 ] Department of Clinical Chemistry, Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Pirkanmaa Hospital District and Fimlab Laboratories, Tampere, Finland. Emma.Raitoharju@tuni.fi.

[21 ] Centre for Population Health Research, University of Turku, Turku University Hospital, Turku, Finland. Emma.Raitoharju@tuni.fi.

Article

Publisher Item ID: 10.1186/s13148-021-01132-3

DOI: 10.1186/s13148-021-01132-3

PMC ID: 8296652

PubMed ID: 34294131

SO-VID: 4aa82dba-e30d-448f-881a-071d71188afc

History

Keywords: vtRNA2-1,nc886,miR-886,Population studies,Genomic imprinting

Data availability:

Keywords: vtRNA2-1, nc886, miR-886, Population studies, Genomic imprinting

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