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Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach
Marc Leushacke ,
Si Hui Tan ,
Angeline Wong ,
Yada Swathi ,
Amin Hajamohideen ,
Liang Thing Tan ,
Jasmine Goh ,
Esther Wong ,
Simon L. I. J. Denil ,
Kazuhiro Murakami ,
Nick Barker
June 5 2017
June 5 2017
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Abstract
Leushacke et al. provide insights into the role of Lgr5 cells in the oxyntic stomach, demonstrating that they label a subpopulation of chief cells that function as reserve stem cells during regeneration and cells-of-origin of gastric cancer.