Mahmoud H. Elbatreek:
ORCID: https://orcid.org/0000-0003-2437-1773
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: MethodologyRole:
Project administrationRole: VisualizationRole: Writing – original draftRole: Writing
– review & editing
Sepideh Sadegh: Role: Data curationRole: Formal analysisRole: MethodologyRole: Software
Elisa Anastasi:
ORCID: https://orcid.org/0000-0002-8701-2295
Role: Formal analysisRole: MethodologyRole: Software
Emre Guney:
ORCID: https://orcid.org/0000-0002-3466-6535
Role: ConceptualizationRole: MethodologyRole: SoftwareRole: Writing – review & editing
Cristian Nogales:
ORCID: https://orcid.org/0000-0001-7535-0417
Role: MethodologyRole: SoftwareRole: Visualization
Tim Kacprowski:
ORCID: https://orcid.org/0000-0002-5393-2413
Role: Data curationRole: Formal analysisRole: MethodologyRole: SoftwareRole: Writing
– review & editing
Ahmed A. Hassan:
ORCID: https://orcid.org/0000-0002-9725-2794
Role: Data curationRole: Formal analysisRole: MethodologyRole: SoftwareRole: Writing
– review & editing
Andreas Teubner: Role: Writing – review & editing
Po-Hsun Huang: Role: Formal analysisRole: MethodologyRole: ResourcesRole: Validation
Chien-Yi Hsu: Role: Formal analysisRole: MethodologyRole: ResourcesRole: Validation
Paul M. H. Schiffers:
ORCID: https://orcid.org/0000-0002-4963-7219
Role: MethodologyRole: Resources
Ger M. Janssen: Role: MethodologyRole: Resources
Pamela W. M. Kleikers: Role: Formal analysisRole: Methodology
Anil Wipat:
ORCID: https://orcid.org/0000-0001-7310-4191
Role: InvestigationRole: Software
Jan Baumbach: Role: ConceptualizationRole: Funding acquisitionRole: SupervisionRole: Writing – review
& editing
Jo G. R. De Mey: Role: ConceptualizationRole: ResourcesRole: SupervisionRole: Writing – original draftRole:
Writing – review & editing
Harald H. H. W. Schmidt:
ORCID: https://orcid.org/0000-0003-0419-5549
Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: Project administrationRole:
ResourcesRole: SupervisionRole: VisualizationRole: Writing – original draftRole: Writing
– review & editing
Cecilia W. Lo: Role: Academic Editor
Journal ID (nlm-ta): PLoS Biol
Journal ID (iso-abbrev): PLoS Biol
Journal ID (publisher-id): plos
Journal ID (pmc): plosbiol
Title:
PLoS Biology
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1544-9173
ISSN
(Electronic):
1545-7885
Publication date
(Electronic):
10
November
2020
Publication date Collection:
November
2020
Publication date PMC-release: 10
November
2020
Volume: 18
Issue: 11
Electronic Location Identifier: e3000885
Affiliations
[1
]
Department of Pharmacology and Personalised Medicine, School for Mental Health and
Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands
[2
]
Department of Pharmacology and Toxicology, School of Pharmacy, Zagazig University,
Zagazig, Egypt
[3
]
Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan, Technical
University of Munich, Munich, Germany
[4
]
School of Computing, Newcastle University, Newcastle, United Kingdom
[5
]
Research Programme on Biomedical Informatics, The Hospital del Mar Medical Research
Institute and Pompeu Fabra University, Barcelona, Spain
[6
]
Division of Data Science in Biomedicine, Peter L. Reichertz Institute for Medical
Informatics of TU Braunschweig and Hannover Medical School, Brunswick, Germany
[7
]
Central Animal Facility, CPV, Maastricht University, Maastricht, the Netherlands
[8
]
Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
[9
]
Department of Critical Care Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
[10
]
Division of Cardiology and Cardiovascular Research Center, Taipei Medical University
Hospital, Taipei, Taiwan
[11
]
Taipei Heart Institute, Division of Cardiology, Department of Internal Medicine, School
of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
[12
]
Department of Pharmacology and Toxicology, Cardiovascular Research Institute Maastricht
(CARIM), Maastricht University, Maastricht, the Netherlands
[13
]
Department of Mathematics and Computer Science, University of Southern Denmark, Odense,
Denmark
University of Pittsburgh, UNITED STATES
Author notes
The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PBIOLOGY-D-20-00252
DOI: 10.1371/journal.pbio.3000885
PMC ID: 7654809
PubMed ID: 33170835
SO-VID: 49efec6e-03c6-4387-8096-5a6e65c3f4f5
Copyright © © 2020 Elbatreek et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: H2020 European Research Council (AdG RadMed)
Award ID: 294683
Award Recipient
:
ORCID: https://orcid.org/0000-0003-0419-5549
Harald H. H. W. Schmidt
Funded by: H2020 European Research Council (PoC SAVEBRAIN)
Award ID: 737586
Award Recipient
:
ORCID: https://orcid.org/0000-0003-0419-5549
Harald H. H. W. Schmidt
Funded by: Horizon 2020 (REPO-TRIAL)
Award ID: 777111
Award Recipient
:
ORCID: https://orcid.org/0000-0003-0419-5549
Harald H. H. W. Schmidt
Funded by: VILLUM Young Investigator grant.
Award ID: 13154
Award Recipient
:
Jan Baumbach
J.B. is grateful for financial support of his VILLUM Young Investigator grant (no.
13154). Financial support to H.H.H.W.S. by the ERC (AdG RadMed '294683' and PoC SAVEBRAIN
'737586') and the Horizon 2020 programme (REPO-TRIAL '777111') is gratefully acknowledged.
This reflects only the author's view and the European Commission is not responsible
for any use that may be made of the information it contains. The funders had no role
in study design, data collection and analysis, decision to publish, or preparation
of the manuscript.
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Vascular Medicine
Subject:
Blood Pressure
Subject:
Hypertension
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Blood Vessels
Subject:
Arteries
Subject:
Femoral Arteries
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Blood Vessels
Subject:
Arteries
Subject:
Femoral Arteries
Subject:
Medicine and Health Sciences
Subject:
Vascular Medicine
Subject:
Blood Pressure
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Mouse Models
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Blood Vessels
Subject:
Arteries
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Blood Vessels
Subject:
Arteries
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Neurochemistry
Subject:
Neurochemicals
Subject:
Nitric Oxide
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Neurochemistry
Subject:
Neurochemicals
Subject:
Nitric Oxide
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Epithelial Cells
Subject:
Endothelial Cells
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Epithelium
Subject:
Epithelial Cells
Subject:
Endothelial Cells
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Epithelium
Subject:
Epithelial Cells
Subject:
Endothelial Cells
Subject:
Research and Analysis Methods
Subject:
Mathematical and Statistical Techniques
Subject:
Statistical Methods
Subject:
Analysis of Variance
Subject:
Physical Sciences
Subject:
Mathematics
Subject:
Statistics
Subject:
Statistical Methods
Subject:
Analysis of Variance
