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The English Version of the Gilles de la Tourette Syndrome–Quality of Life Scale for Children and Adolescents (C&A-GTS-QOL) : A Validation Study in the United Kingdom
Merina T. Su
1
,
2 ,
Fiona McFarlane
2 ,
Andrea E. Cavanna
3
,
4
,
5 ,
Cristiano Termine
6 ,
Imogen Murray
2 ,
Larissa Heidemeyer
2 ,
Isobel Heyman
1
,
2 ,
Tara Murphy
1
,
2
December 16 2016
September 30 2016
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Abstract
<p class="first" id="d8069305e160">Gilles de la Tourette syndrome is a chronic neuropsychiatric
disorder that can have
a detrimental impact on the health-related quality of life of children with the condition.
To date no patient-reported health-related quality of life measures have been developed
for children and adolescents in the English language. This study validated the first
disease-specific scale for the quantitative assessment of health-related quality of
life in 118 children and adolescents with Gilles de la Tourette syndrome (C&A-GTS-QOL)
following language adaptation from Italian to English in the United Kingdom. Standard
statistical methods were used to test the psychometric properties of the rating scale.
Principal component factor analyses led to the identification of six health-related
quality of life domains (cognitive, copro-phenomena, psychological, physical, obsessive-compulsive,
and activities of daily living), explaining 66.7% of the overall variance. The C&A-GTS-QOL
demonstrated satisfactory scaling assumptions and acceptability; validity was supported
by interscale correlations (range 0.2-0.7), confirmatory factor analysis, and correlation
patterns with other rating scales and clinical variables.
</p>